Lactic Acid Bacteria T Cell Apoptosis Inducer
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Solution Overview
Problem
Current methods fail to effectively induce apoptosis of excess T cells, leading to autoimmune diseases and allergies, as they disrupt the Th1/Th2 balance, necessitating a safe and novel approach to modulate the immune system.
Innovation Solution
Utilizing lactic acid bacterial strains from the genus Lactobacillus or Bifidobacterium, such as Lactobacillus amylovorus CP1750, Bifidobacterium catenulatum CP2829, and Bifidobacterium longum CP760, to induce apoptosis of excess T cells, which are safe for long-term oral consumption and can be incorporated into food or pharmaceutical preparations.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional methods are used to induce apoptosis of excess T cells, then apoptosis induction is achieved, but the Th1/Th2 balance is disrupted and safety is compromised
Solution Approach 1:
The patent changes the parameters of the inducing agent by using specific lactic acid bacterial strains (Lactobacillus and Bifidobacterium genera) with defined characteristics, replacing conventional apoptosis inducers. This parameter change enables selective T cell apoptosis while maintaining Th1/Th2 balance and ensuring safety through the use of benign, food-grade bacteria.
Solution Approach 2:
The lactic acid bacteria serve as an intermediary substance that mediates the apoptosis induction process. Instead of direct toxic agents, the patent employs these bacteria as a safe mediator that triggers apoptosis through controlled mechanisms, thereby avoiding direct harm while achieving the desired therapeutic effect.
2Reliability
If lactic acid bacteria are used to induce T cell apoptosis, then safety is improved and Th1/Th2 balance is maintained, but the mechanism of action is complex
Solution Approach 1:
The patent segments the complex mechanism into identifiable components: specific bacterial strains (Lactobacillus and Bifidobacterium), their interaction with T cells, and the resulting apoptosis pathway. This segmentation allows for systematic understanding and control of the mechanism while maintaining safety benefits.
Data Source
AI summary
An inducer of T cell apoptosis and a health food for inducing T cell apoptosis comprising as an active ingredient of a lactic acid bacterium belonging to the genus Lactobacillus or the genus Bifidobacterium are disclosed. Particularly preferred lactic acid bacteria belonging to the genus Lactobacillus or the genus Bifidobacterium are Lactobacillus acidophilus L-92 (FERM BP-4981), Lactobacillus amylovorus CP1750 (FERM BP-10532), Bifidobacterium catenulatum CP2829 (FERM BP-10533) and Bifidobacterium longum CP760 (FERM BP-10531). The inducer of T cell apoptosis of the invention is useful in the prevention and cure of a disease such as an organ-specific autoimmune disease or type I allergy.