Lactobacillus Strains for Selective Immune Modulation
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Current immune-modulating substances fail to effectively strengthen the immune response by selectively targeting T helper 1 or T helper 2 cells, leading to inadequate defense against various pathogens and illnesses, particularly with the rise of antibiotic-resistant microorganisms.
Innovation Solution
A pharmaceutical and dietetic composition containing specific strains of Lactobacillus fermentum and Lactobacillus plantarum bacteria, such as K1-Lb1, K2-Lb6, K4-Lb6, and K7-Lb1, which stimulate T helper cells to enhance immune responses, shifting the balance between T helper 1 and T helper 2 cells to combat specific illnesses.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If conventional immune-modulating substances are used, then general immune support is provided, but selective targeting of T helper 1 or T helper 2 cells is insufficient
Solution Approach 1:
The invention segments the immune modulation function by using different Lactobacillus strains that specifically target different T helper cell types. L. fermentum strains selectively modulate T helper 1 responses, while L. plantarum strains selectively modulate T helper 2 responses, enabling precise targeting of specific immune pathways rather than general immune support.
Solution Approach 2:
The invention applies local quality by matching specific bacterial strains to specific immune conditions. Each strain exhibits localized effectiveness for particular T helper cell types, allowing tailored immune modulation based on the specific immune imbalance present in the patient.
2Reliability
If antibiotic-resistant microorganisms emerge, then conventional treatments become less effective, but alternative immune-strengthening solutions are needed
Solution Approach 1:
The invention provides universal immune support by strengthening the body's own defense mechanisms through probiotic bacteria. The selected Lactobacillus strains enhance both T helper 1 and T helper 2 mediated immunity, creating a versatile defense system that can respond to various pathogens including antibiotic-resistant microorganisms through enhanced natural immunity rather than direct antimicrobial action.
3Measurement precision
If Th1/Th2 response is influenced to combat specific illnesses, then targeted immune response is achieved, but balance between natural and adaptive immunity must be maintained
Solution Approach 1:
The invention modifies immune response parameters by using specific Lactobacillus strains that shift the Th1/Th2 balance in a controlled manner. L. fermentum increases T helper 1 activity parameters, while L. plantarum increases T helper 2 activity parameters, allowing precise adjustment of immune response characteristics while maintaining overall immune system stability through natural probiotic mechanisms.
Data Source
AI summary
The invention relates to a pharmaceutical and/or dietetic composition for increasing the impact of the immune defense of higher living beings, wherein bacteria of the species Lactobacillus fermentum from at least one of the strains K1-Lb1 or K1-Lb6 or K2-Lb4 or K6-Lb4 or K7-Lb1 or K8-Lb1 or K9-Lb6 are contained in order to control the adaptive and natural immune defense by means of T helper 1 and T helper 2 cells and/or bacteria of the species Lactobacillus fermentum from at least one of the strains K2-Lb6 or K11-Lb3 are contained in order to strengthen the native immune defense.