Lactobacillus Membrane Vesicles for Periodontal Pathogen Inhibition
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Solution Overview
Problem
Current technologies lack effective inhibitors to control the growth of periodontal pathogens such as Fusobacterium, Porphyromonas, and Tannerella, which are associated with periodontal diseases and other health issues like colorectal cancer.
Innovation Solution
Incorporating membrane vesicles from Lactobacillus reuteri and Lactobacillus casei to inhibit the growth of these pathogens, either alone or in combination with other additives.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional antibiotics or antimicrobial agents are used, then bacterial growth inhibition is achieved, but resistance development and ecological disruption occur
Solution Approach 1:
The patent uses membrane vesicles from Lactobacillus as an intermediary substance that mediates the inhibition of periodontal pathogens. These vesicles contain antimicrobial components that can suppress pathogen growth without requiring direct contact with antibiotic agents, thereby avoiding resistance development while maintaining ecological balance in the oral microbiome
Solution Approach 2:
The invention changes the parameter of the inhibiting agent from conventional antibiotics to membrane vesicles derived from beneficial bacteria. This parameter change transforms the mechanism of action from direct antimicrobial killing to a more subtle modulation that prevents pathogen overgrowth while preserving beneficial oral flora, thus avoiding the harmful effects of traditional antibiotics
2Object-affected harmful factors
If no specific inhibitor is used, then oral microbiome balance is maintained, but periodontal pathogen overgrowth occurs leading to disease
Solution Approach 1:
The patent employs membrane vesicles from Lactobacillus species that naturally occur in the oral cavity. These vesicles represent a self-service mechanism where beneficial bacteria produce inhibitory substances that automatically regulate pathogen populations, maintaining microbiome balance without external intervention. This self-regulating system prevents pathogen overgrowth while preserving the natural ecological relationships in the oral environment
Solution Approach 2:
The invention extracts the active inhibitory components from Lactobacillus bacteria in the form of membrane vesicles. These vesicles contain the essential antimicrobial factors that can be isolated and applied to prevent periodontal pathogen overgrowth, separating the beneficial inhibitory function from the whole bacterial cell and enabling targeted therapy
Data Source
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AI summary
An object is to provide a novel active ingredient to inhibit the growth of a periodontal pathogen. [Solution] The periodontal pathogen growth inhibitor of the present invention is characterized by including at least one of membrane vesicles of Lactobacillus reuteri and membrane vesicles of Lactobacillus casei. The method for inhibiting the growth of a periodontal pathogen of the present invention is characterized in that the periodontal pathogen growth inhibitor of the present invention and a periodontal pathogen are allowed to coexist. The periodontal pathogen is, for example, bacteria of the genus Fusobacterium, bacteria of the genus Porphyromonas and bacteria of the genus Tannerella.