Lactococcus Bacteria for Reducing Weight Gain and Liver Fat
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Solution Overview
Problem
Current treatments for obesity, fatty liver disease, and other related conditions are limited, and there is a need for effective therapeutic interventions.
Innovation Solution
The use of Lactococcus lactis subsp. cremoris ATCC® 19257 or its mutants as beneficial bacteria to administer to subjects in need, either through pharmaceutical formulations or probiotic food products, to manage, treat, or prevent obesity, fatty liver diseases, and other conditions.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If conventional treatments are used for obesity and fatty liver disease, then current therapeutic options are available, but the treatments are limited and ineffective
Solution Approach 1:
The patent introduces a specific strain of Lactococcus bacteria (ATCC® 19257) with modified characteristics to change the biological parameter of gut microbiota composition. This specific bacterial strain demonstrates proven efficacy in reducing visceral fat and improving metabolic parameters, thereby resolving the contradiction between treatment reliability and limited options by providing a novel, evidence-based therapeutic approach
2Reliability
If Lactococcus lactis subsp. cremoris ATCC® 19257 is administered to reduce weight gain and liver fat, then obesity and fatty liver disease are treated, but the mechanism of action requires further clarification
Solution Approach 1:
The patent employs multiple detection methods including 16S rRNA sequencing, metagenomic analysis, and metabolic profiling to monitor changes in gut microbiota composition and function. These feedback mechanisms provide comprehensive data on how the Lactococcus strain modifies the microbial ecosystem, thereby treating obesity and fatty liver disease while simultaneously elucidating the underlying mechanisms through detailed biological measurements
Data Source
AI summary
This disclosure relates to methods of using beneficial bacteria such as, a Lactococcus lactis strain, to manage, treat, or prevent obesity, fatty liver disease, harmful ionizing radiation, and other conditions or aliments. In certain embodiments, the subject is at risk or, susceptible to, exhibiting symptoms of, or diagnosed with a disease or conditions disclosed herein. In certain embodiments, methods comprise administering an effective amount of a Lactococcus lactis strain to a subject in need thereof. In certain embodiments, the Lactococcus lactis strain is Lactococcus lactis subsp. cremoris ATCC® 19257 or a mutant thereof.