Lactoferrin Protects Intestinal Neuronal Cells

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Solution Overview

Problem

Impaired enteric nervous system disorders lead to intestinal dysfunctions, malnutrition, and increased infection risks due to neuronal degeneration and loss, particularly in aging or pathological conditions such as diabetes and intestinal inflammation.

Innovation Solution

A composition enriched with lactoferrin, which can be derived from milk or produced recombinantly, is administered to protect and promote the growth of intestinal neuronal cells, thereby preventing neuronal death and enhancing repair processes.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If conventional treatments are used for impaired enteric nervous system, then neuronal loss and degeneration occur, but intestinal dysfunctions and infection risks increase

Engineering Contradiction:

Improveneuronal survivalVSAvoidintestinal dysfunctions

Core Design Contradiction:

ReliabilityVSObject-affected harmful factors

Solution Approach 1:

Lactoferrin acts as a mediator substance that protects intestinal neuronal cells from stress-induced damage and promotes neuronal survival. The patent demonstrates that lactoferrin administration prevents neuronal loss and supports enteric nervous system function, thereby preventing intestinal dysfunctions without causing harmful side effects.

Inventive Principle:

Principle #24Intermediary (Mediator)

Solution Approach 2:

The patent utilizes changes in lactoferrin concentration and administration parameters to achieve neuronal protection. By optimizing the dosage and delivery form of lactoferrin, the treatment effectively promotes neuronal survival and prevents intestinal dysfunctions associated with enteric nervous system impairment.

Inventive Principle:

Principle #35Parameter changes

2Quantity of substance

If neuronal cells are protected from stress, then neuron density increases, but this requires specific lactoferrin administration

Engineering Contradiction:

Improveneuron densityVSAvoidlactoferrin production

Core Design Contradiction:

Quantity of substanceVSEase of manufacture

Solution Approach 1:

Lactoferrin is extracted or isolated from milk sources to create a purified composition suitable for therapeutic administration. This extraction process enables the concentration of lactoferrin to achieve effective neuronal protective doses while maintaining ease of production through well-established dairy processing techniques.

Inventive Principle:

Principle #2Taking out (Extraction)

3Duration of action of stationary object

If lactoferrin is used to promote neuronal growth, then repair processes are enhanced, but this requires sustained administration

Engineering Contradiction:

Improveneuronal repair durationVSAvoidtreatment time

Core Design Contradiction:

Duration of action of stationary objectVSLoss of time

Solution Approach 1:

The patent employs sustained administration of lactoferrin to maintain continuous protective and reparative effects on intestinal neuronal cells. This continuous action ensures prolonged neuronal survival support and repair promotion, addressing the extended treatment duration required for effective enteric nervous system recovery.

Inventive Principle:

Principle #20Continuity of useful action

Data Source

PatentUS9095570B2Lactoferrin and gut neuronal health in adults and/or elderly

Publication Date: 2015.08.04 SOCIETE DES PRODUITS NESTLE SA

AI summary

The present invention relates generally to the field of neuronal health and neuronal protection. One embodiment of the present invention relates to a composition that can be used for the protection of the enteric nervous system from neurodegeneration. Disorders linked to an impaired enteric nervous system can be treated or prevented by the administration of lactoferrin containing compositions according to the present invention.