Laminated ECM Pouch for Tissue Regeneration
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Solution Overview
Problem
Current extracellular matrix compositions for tissue regeneration lack improved regenerative capabilities and effective delivery methods for inducing tissue repair and wound healing.
Innovation Solution
Development of bioremodelable ECM structures with laminated sheets of small intestine submucosa, liver basement membrane, and urinary bladder submucosa, incorporating mesenchymal or pluripotent cells and growth factors like FGF-2 or VEGF, to form a pouch structure that supports tissue regeneration and wound healing by providing structural support and biological activity.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If traditional extracellular matrix compositions are used for tissue regeneration, then basic structural support is provided, but regenerative capabilities and wound healing effectiveness are insufficient
Solution Approach 1:
The patent combines multiple types of extracellular matrix materials (small intestine submucosa, liver basement membrane, urinary bladder submucosa) into a composite structure. This composite approach integrates the advantages of each individual matrix type, providing both structural support and enhanced biological activity for improved tissue regeneration and faster wound healing
Solution Approach 2:
The invention merges multiple functional components into a single integrated structure: different ECM materials, living cells, and growth factors are combined within a unified pouch structure. This merging creates synergistic effects where the components work together to enhance both the reliability of tissue regeneration and the productivity of wound healing
2Strength
If ECM compositions are used alone, then basic tissue support is provided, but structural support and biological activity are insufficient for optimal regeneration
Solution Approach 1:
The patent creates a composite structure combining rigid ECM scaffolds for structural integrity with biologically active components (cells and growth factors) for adaptive regeneration. The composite nature allows simultaneous provision of mechanical strength and biological versatility
Solution Approach 2:
The invention segments the functional requirements into distinct components: structural support is provided by the ECM scaffold while biological activity is provided by encapsulated cells and growth factors. This segmentation allows each component to optimize its specific function while working together as an integrated system
Data Source
AI summary
An extracellular matrix (ECM) structure for tissue regeneration, the ECM structure having a a sheet member comprising small intestine submucosa (SIS), the SIS sheet member being folded and laminated proximate the sheet member edge, wherein a folded laminated ECM structure having a cavity therein is formed, the ECM structure further including an ECM composition that is disposed in the ECM structure cavity, the ECM composition including liver basement membrane, urinary bladder submucosa, a mesenchymal stem cell and a growth factor.