Laminated Manifold for Sensor Reagent Delivery
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Solution Overview
Problem
Current cartridges for biological or chemical analysis are inefficient in handling liquid reagents due to a long fluidic path from the reagent storage area through a conventional manifold to the sensor, leading to slow analysis and excessive use of wash reagent.
Innovation Solution
The introduction of a laminated manifold attached to a circuit with sensors, featuring an electrical interconnect and sealed fluidic channels, to efficiently deliver liquid reagents over the active surface of the sensors.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Productivity
If a conventional manifold is used with a long fluidic path from reagent storage to sensor, then the manifold can deliver liquid reagents, but the analysis speed is slow and large volumes of wash reagent are consumed
Solution Approach 1:
The patent transitions from a conventional three-dimensional manifold structure to a two-dimensional laminated manifold where fluidic channels are formed as planar pathways between stacked layers. This dimensional reduction allows the fluidic path to be significantly shortened while maintaining the necessary fluid delivery functionality, directly addressing the slow analysis speed and time consumption issues.
Solution Approach 2:
The manifold is segmented into multiple thin laminated layers, each containing specific fluidic channels or structures. This segmentation allows for optimized fluid pathways within each layer, reducing the overall path length from reagent storage to sensor compared to a monolithic manifold design.
2Quantity of substance
If a conventional manifold with long fluidic path is used, then reagent delivery is achieved, but large volumes of wash reagent are required
Solution Approach 1:
By reducing the fluidic path length through dimensional change from 3D to 2D laminated structure, the total volume of wash reagent required to clear the fluidic path is significantly reduced, directly addressing the excessive wash reagent consumption problem.
Solution Approach 2:
The patent changes the geometric parameters of the fluidic path by implementing a laminated structure with shorter channel lengths and optimized cross-sectional areas, thereby reducing the total volume of reagent needed for both analysis and washing operations.
3Productivity
If a laminated manifold is used to reduce fluidic path length, then analysis speed is improved, but the manufacturing complexity increases
Solution Approach 1:
The patent changes the manufacturing approach by using standard lamination techniques and common materials, transforming a potentially complex 3D manufacturing problem into a more manageable 2D layering process that can be achieved through established manufacturing methods.
Data Source
AI summary
A circuit with electrical interconnect for external electronic connection and sensor(s) on a die are combined with a laminated manifold to deliver a liquid reagent over an active surface of the sensor(s). The laminated manifold includes fluidic channel(s), an interface between the die and the fluidic channel(s) being sealed. Also disclosed is a method, the method including assembling a laminated manifold including fluidic channel(s), attaching sensor(s) on a die to a circuit, the circuit including an electrical interconnect, and attaching a planarization layer to the circuit, the planarization layer including a cut out for the die. The method further includes placing sealing adhesive at sides of the die, attaching the laminated manifold to the circuit, and sealing an interface between the die and fluidic channel(s).