Engineered Landing Zone Prosthesis for Short Neck Aneurysms
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Solution Overview
Problem
Aneurysms with unfavorable anatomy, such as short or highly angled necks, pose challenges for endovascular repair due to the lack of a suitable proximal neck for stent graft deployment, limiting the number of patients that can be treated with conventional endovascular approaches.
Innovation Solution
An engineered landing zone prosthesis is delivered to the aorta in a radially compressed configuration, with a frame and graft material, where the engineered landing zone remains compressed and is longitudinally spaced from the frame, allowing for secure anchoring and subsequent expansion to create a stable landing zone for stent graft deployment, even in anatomies with unsuitable necks.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Adaptability or versatility
If conventional endovascular repair is used, then treatment is simple and quick, but it cannot be applied to patients with short or highly angled necks
Solution Approach 1:
The device is divided into three main segments: a proximal frame for anchoring, a non-stented graft portion, and a distal engineered landing zone. This segmentation allows each component to perform its specific function - the frame anchors to the vessel wall, the graft provides exclusion, and the engineered landing zone creates a suitable seal zone - thereby enabling treatment of unfavorable anatomy without requiring the entire device to be complex
Solution Approach 2:
The engineered landing zone is delivered in a compressed state within the delivery system, allowing it to be positioned first and expanded to create a stable seal zone before the main graft is deployed. This preliminary action prepares the anatomical site in advance, making it suitable for subsequent graft placement even when the native anatomy is unfavorable
2Reliability
If a stable landing zone is created through engineered landing zone deployment, then stent graft anchoring is improved, but the device structure becomes more complex
Solution Approach 1:
The engineered landing zone is nested within the delivery system catheter in a compressed configuration, allowing it to be delivered through the vasculature without excessive complexity. Once positioned, it is deployed and then the main graft is delivered through or alongside it, creating a nested configuration that provides stable anchoring while maintaining delivery feasibility
Solution Approach 2:
The engineered landing zone acts as an intermediary structure between the proximal frame and the distal graft portion. It provides a stable seal zone that mediates the connection between these components, ensuring reliable anchoring while allowing the overall device structure to remain manageable through modular design
3Ease of operation
If the engineered landing zone is delivered in compressed configuration, then delivery is facilitated, but the landing zone cannot provide structural support until expanded
Solution Approach 1:
The engineered landing zone transitions from a dynamic compressed state during delivery to a static expanded state upon deployment. This dynamic design allows the device to be easily delivered through the vasculature in a low-profile compressed configuration, then provides the necessary structural support and radial strength once expanded at the target site
4Adaptability or versatility
If the non-stented portion of graft material is used, then flexibility is improved, but radial strength is reduced
Solution Approach 1:
The graft is designed with heterogeneous structure where different portions have different properties: the proximal and distal portions contain stents for radial strength and anchoring, while the intermediate non-stented portion provides flexibility and conformability. This local differentiation allows each section to optimize its function - the stented sections provide structural support where needed, while the non-stented section provides flexibility for navigation and adaptation to vessel geometry
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This solution enables the deployment of stent grafts in anatomies with unsuitable necks, providing a stable landing zone and allowing for effective treatment of aneurysms that would otherwise be inaccessible with traditional methods.
Implementation Method 1
radially expanding the frame at the site of the aneurysm, wherein with the frame radially expanded, the engineered landing zone remains in the radially compressed configuration
Implementation Method 2
securing the frame to the vessel comprises delivering endoanchors to within the frame, and deploying the endoanchors through the frame and into the vessel to secure the frame to the vessel
Implementation Method 3
longitudinally translating the engineered landing zone such that the engineered landing zone is at least partially disposed within the frame
Implementation Method 4
radially expanding the engineered landing zone
Implementation Method 5
graft material coupled at a first end to the frame and at a second end to the engineered landing zone
Data Source
AI summary
A method for creating an engineered landing zone includes delivering a landing zone prosthesis in a radially compressed configuration to a site of an aneurysm within a vessel. The landing zone prosthesis includes a frame, an engineered landing zone, and graft material coupled at a first end to the frame and at a second end to the engineered landing zone. The method further includes radially expanding the frame at the site of the aneurysm while the engineered landing zone remains in the radially compressed configuration longitudinally spaced from the frame, securing to the vessel, longitudinally translating the engineered landing zone such that the engineered landing zone is at least partially disposed within the frame, and radially expanding the engineered landing zone.