Lapachol Skin Cream Composition for Suspension Stability
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Solution Overview
Problem
Lapachol, when incorporated into the aqueous phase of water-based creams, tends to fall out of suspension, leading to reduced shelf life and stability issues.
Innovation Solution
Incorporating lapachol into the oil phase of a water-based cream formulation and then combining it with the aqueous phase, ensuring it remains suspended and stable, thereby extending the product's shelf life.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of operation
If lapachol is incorporated into the aqueous phase of water-based creams, then the product is suitable for face and eye use, but lapachol falls out of suspension reducing shelf life
Solution Approach 1:
The patent uses an anhydrous phase (oil phase containing ingredients like caprylic/capric triglyceride, shea butter, and sunflower seed oil) as an intermediary to suspend lapachol before incorporating it into the aqueous phase. This intermediary phase prevents direct contact between lapachol and water, avoiding precipitation while maintaining stability in the final water-based formulation suitable for face and eye products.
Solution Approach 2:
The patent changes the physical-chemical parameters of the formulation by creating a multi-phase system where lapachol is first dissolved in the anhydrous phase at elevated temperatures, then incorporated into the aqueous phase upon cooling. This parameter change (temperature and phase distribution) allows lapachol to remain suspended without falling out of solution, extending shelf life while maintaining suitability for sensitive areas.
2Object-affected harmful factors
If lapachol is suspended in the aqueous phase, then the formulation is water-based and gentle for sensitive skin, but stability is compromised causing lapachol to precipitate
Solution Approach 1:
The anhydrous phase acts as a protective intermediary that maintains lapachol in suspension without direct aqueous contact. This intermediary layer preserves the gentleness of water-based formulations for sensitive skin while preventing the stability issue of precipitation, as the oil-soluble anhydrous phase keeps lapachol dispersed throughout the water-based cream.
Solution Approach 2:
The patent creates a composite formulation combining aqueous and anhydrous phases with lapachol distributed throughout. This composite structure integrates the benefits of water-based gentle formulations with the stability-providing properties of the anhydrous phase, resulting in a stable cream that remains effective throughout its shelf life without compromising skin compatibility.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The method maintains lapachol's activity and prevents it from falling out of suspension, ensuring the cream's stability and effectiveness for at least 3 months.
Implementation Method 1
incorporating lapachol into the oil phase of a water-based cream formulation and then combining it with the aqueous phase, ensuring it remains suspended and stable
Data Source
AI summary
A water-based composition containing lapachol is provided that includes water, a plurality of water-based and/or water-soluble components, a plurality of oil based and/or soluble components, lapachol. The lapachol is dissolved within one or more of the plurality of oil based and/or soluble components.