Laser Ablation Regression Analysis for Reproducible Solid Samples
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Solution Overview
Problem
Existing methods for analyzing solid samples, such as LA-ICP-MS and LA-ICP-OES, require pre-treatments like mixing resin powder with the sample and heating, making them cumbersome and lacking reproducibility, especially for powder samples.
Innovation Solution
An analysis method that involves creating a regression equation based on signal intensity and removal volume of the analysis object in a standard sample film, allowing direct laser irradiation of a laminate without pre-treatment, using operations like disposing and detecting signal intensities in standard and analysis samples to calculate the analysis object's concentration.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If pre-treatment methods like mixing resin powder with sample and heating are used, then analysis reproducibility is improved, but analysis complexity and time consumption increase
Solution Approach 1:
The invention extracts and removes the pre-treatment step (mixing resin powder and heating) from the analysis process. By using a laser ablation method that directly analyzes the sample without requiring resin embedding, the complex pre-treatment procedures are eliminated while maintaining analysis reproducibility through standardized laser parameters and direct measurement of the sample surface.
Solution Approach 2:
The invention segments the analysis process into distinct operational phases: sample preparation (simple mounting), laser ablation (controlled material removal), and analysis (spectral measurement). This segmentation allows each phase to be optimized independently, with the laser ablation phase providing consistent, reproducible results without requiring the integrated complex pre-treatment of resin mixing and heating.
2Reliability
If pre-treatment methods like mixing resin powder with sample and heating are used, then analysis reproducibility is improved, but analysis time increases
Solution Approach 1:
The invention performs preliminary laser ablation on standardized sample mounts to create a consistent analysis surface before measurement. This preliminary action ensures reproducibility by removing surface irregularities and creating a uniform ablation zone, eliminating the need for time-consuming resin mixing and heating pre-treatments while maintaining consistent analytical results.
Solution Approach 2:
The invention skips the intermediate pre-treatment steps (resin mixing, heating, cooling, demolding) by using direct laser ablation on solid or powdered samples mounted on simple substrates. This rushing through of the analysis process to the core measurement phase significantly reduces total analysis time while maintaining reproducibility through controlled laser parameters and standardized mounting procedures.
3Ease of operation
If direct laser irradiation without pre-treatment is used, then analysis simplicity is improved, but measurement reliability may worsen
Solution Approach 1:
The invention controls measurement reliability through precise parameter management in the direct laser ablation process. By optimizing and standardizing laser parameters (wavelength, pulse duration, energy density, repetition rate) and sample mounting conditions, the method achieves reproducible results without pre-treatment, balancing simplicity with reliability through parameter control rather than complex procedural steps.
Solution Approach 2:
The invention incorporates feedback mechanisms to ensure measurement reliability in the simplified direct ablation process. Real-time monitoring of ablation depth, plasma emission intensity, and spectral signal quality allows dynamic adjustment of laser parameters during analysis, maintaining consistent measurement reliability while preserving the simplicity of the direct irradiation approach without resin pre-treatment.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Enables simple and reproducible analysis of solid samples without pre-treatment, maintaining sample integrity and improving measurement reliability.
Implementation Method 1
irradiating the laminate for analysis with laser light
Implementation Method 2
laser-induced breakdown spectroscopy (LIBS)
Implementation Method 3
the gas or the fine particles derived from the solid sample during the irradiation with laser light are introduced into an inductively coupled plasma
Implementation Method 4
laser-ablation-inductively coupled plasma-optical emission spectrometry (LA-ICP-OES)
Implementation Method 5
laser ablation-inductively coupled plasma-mass spectrometry (LA-ICP-MS)
Data Source
Figure 1A~1B
Figure 2A~2B
Figure 3
AI summary
An object of the present invention is to provide an analysis method in which analysis of an analysis object in a solid sample can be simply performed. An analysis method according to the present invention includes: creating a regression equation based on a value of a signal intensity obtained by performing any one of predetermined operation 1, 2, 3, or 4 and an amount of an analysis object that is removed by laser light irradiation in a standard sample film; and using the regression equation to calculate an amount of the analysis object that is removed by laser light irradiation in a solid analysis sample including the analysis object.