Microfluidic Jet Injection System Using Laser-Induced Boiling

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Solution Overview

Problem

Existing jet injection systems face issues such as low jet velocity, tissue damage, jet splashback, inconsistent jet properties, high energy demands, and fragility, making them inefficient and unsuitable for portable or handheld applications like insulin or veterinary injections.

Innovation Solution

A microfluidic device with a laser-based heating system that generates a jet by boiling liquid using laser radiation, providing consistent jet ejection with controlled velocity, stability, and diameter, and reducing energy requirements, while being portable and non-noisy.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Speed

If rapid vaporization of liquid is used to generate jet, then jet velocity is improved, but energy consumption increases substantially

Engineering Contradiction:
Improvejet velocityVSAvoidenergy consumption
Core Design Contradiction:
SpeedVSUse of energy by moving object

Solution Approach 1:

The patent utilizes phase transition of liquid to vapor through controlled heating. A meniscus is formed in a capillary tube, and rapid vaporization of liquid beneath the meniscus creates a shock front that propels the jet forward. This phase transition mechanism enables high jet velocity while controlling energy consumption through localized heating rather than bulk vaporization.

Inventive Principle:
Principle #36Phase transitions

Solution Approach 2:

The patent employs thermal expansion of liquid to generate pressure for jet ejection. Heating causes the liquid to expand rapidly, creating a shock wave that moves the meniscus forward and generates the jet. This thermal expansion mechanism provides an alternative to mechanical pumping systems, reducing overall energy consumption while maintaining jet velocity.

Inventive Principle:
Principle #37Thermal expansion

2Speed

If high pressure is applied to eject jet, then jet velocity is improved, but tissue damage increases

Engineering Contradiction:
Improvejet velocityVSAvoidtissue damage
Core Design Contradiction:
SpeedVSObject-affected harmful factors

Solution Approach 1:

The patent uses phase transition of liquid to vapor to generate a shock front that propels the jet. This creates a more controlled pressure distribution compared to direct mechanical pressurization, reducing peak pressures that cause tissue damage while maintaining sufficient jet velocity for effective injection.

Inventive Principle:
Principle #36Phase transitions

Solution Approach 2:

The meniscus acts as an intermediary between the heated liquid and the jet ejection process. It converts the thermal energy and pressure from localized heating into a controlled shock front, mediating the energy transfer to achieve high jet velocity without the harmful side effects of uncontrolled high-pressure application.

Inventive Principle:
Principle #24Intermediary (Mediator)

3Ease of operation

If mechanical pumping system is used, then jet ejection is achieved, but device complexity and fragility increase

Engineering Contradiction:
Improvejet ejection capabilityVSAvoidsystem complexity
Core Design Contradiction:
Ease of operationVSDevice complexity

Solution Approach 1:

The patent replaces mechanical pumping systems with a thermal field-based approach. Instead of using mechanical components to generate pressure and eject the jet, the system uses localized heating to induce phase transition and thermal expansion, which naturally generates the pressure needed for jet ejection. This substitution eliminates complex mechanical parts and reduces device fragility.

Inventive Principle:
Principle #28Mechanics substitution (Replace mechanical system)

Solution Approach 2:

The system uses the liquid's own thermal expansion and phase transition properties to generate the pressure needed for ejection. The heated liquid self-generates the shock front and pressure wave required for jet formation, eliminating the need for external mechanical pumping systems and simplifying the overall device architecture.

Inventive Principle:
Principle #25Self-service

4Stability of the object's composition

If consistent jet properties are achieved through precise control, then jet stability is improved, but device complexity increases

Engineering Contradiction:
Improvejet stabilityVSAvoidcontrol system complexity
Core Design Contradiction:
Stability of the object's compositionVSDevice complexity

Solution Approach 1:

The patent uses phase transition as a natural control mechanism. The meniscus formation and subsequent vaporization create a self-regulating process where the phase change itself controls the jet formation. This natural physical phenomenon provides consistent jet properties without requiring complex electronic control systems or sensors.

Inventive Principle:
Principle #36Phase transitions

Solution Approach 2:

The patent controls jet properties by managing thermal parameters (heating rate, temperature distribution) rather than mechanical parameters. By controlling the heating process and thermal diffusion, the system achieves consistent jet velocity, diameter, and stability through thermal field management, which is simpler than mechanical control systems.

Inventive Principle:
Principle #35Parameter changes

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The system achieves efficient, consistent, and controlled jet ejection with lower energy input, reducing tissue damage and splashback, and enabling portable, painless injections with improved resolution and reduced system complexity.

Implementation Method 1

a laser-based heating system configured to provide laser radiation to one or more of the chamber wall and a liquid in the hosting chamber

Methodology Applied
Scientific EffectLaser radiation absorption: Absorption (EM radiation)

Implementation Method 2

generates a jet by boiling liquid using laser radiation

Methodology Applied
Scientific EffectBoiling: Boiling

Implementation Method 3

providing laser radiation to the chamber wall and/or to the liquid such that the liquid is brought to a boil, thereby generating a bubble expanding/moving to the second chamber end, thus displacing the liquid and generating a jet

Methodology Applied
Scientific EffectThermal expansion: Thermal Expansion

Data Source

PatentUS20220153028A1Jet injection system
Publication Date: 2022.05.19 UNIVERSITY OF TWENTE
  • US20220153028A1 patent drawing
  • US20220153028A1 patent drawing
  • US20220153028A1 patent drawing

AI summary

A jet injection system (10) comprising (i) a microfluidic device (100) for jet ejection and (ii) a laser-based heating system (200), wherein: —the microfluidic device (100) comprises a hosting chamber (110) defined by a chamber wall (120), the hosting chamber (110) having a chamber height he selected from the range of 5-400 μm, a chamber width we selected from the range of 2hc-10hc, and a chamber length lc defined by a first chamber end (111) and a second chamber end (112), wherein the second chamber end (112) comprises a first chamber opening (131) for jet ejection from the hosting chamber (110), and wherein the hosting chamber (110) is configured to host a liquid (50); —the laser-based heating system (200) is configured to provide laser radiation (201) to one or more of the chamber wall (120) and a liquid (50) in the hosting chamber (110).