Laser Light Source Rapid Turn-On for Microscopy Illumination

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Solution Overview

Problem

Laser illumination systems in microscopy, particularly in confocal microscopes, face significant deterioration due to continuous operation, leading to aging of components like optics and optical fibers, even when the laser is not actively used for imaging, resulting in reduced output power over time.

Innovation Solution

Implementing a rapid turn-on mechanism for the laser light source triggered by a signal just before image acquisition, utilizing a control system with a monitor photodiode to manage pump source current and separating the laser into a continuously operated seed laser and a downstream amplifier unit, allowing for intermittent operation of critical components only during scanning.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If the laser light source is operated continuously to ensure immediate availability for image acquisition, then the readiness and response time are improved, but the lifespan of sensitive components deteriorates due to aging and thermal stresses

Engineering Contradiction:
Improvelaser readinessVSAvoidcomponent lifespan
Core Design Contradiction:
ReliabilityVSDuration of action of stationary object

Solution Approach 1:

The patent applies preliminary action by keeping the seed laser continuously operating to maintain readiness, while only activating the amplifier unit when needed. This allows the system to be prepared in advance without subjecting all components to continuous stress, thereby extending component lifespan while maintaining immediate availability for imaging.

Inventive Principle:
Principle #10Preliminary action

Solution Approach 2:

The laser light source is segmented into two functional parts: a continuously operating seed laser and an intermittently activated amplifier unit. This segmentation allows the critical amplifier components to remain inactive during non-imaging periods, reducing aging and thermal stress, while the seed laser remains ready to provide immediate input when imaging begins.

Inventive Principle:
Principle #1Segmentation

2Duration of action of stationary object

If the laser light source is turned off during intervals between image acquisitions to reduce aging, then component lifespan is improved, but the time required to become operational again increases

Engineering Contradiction:
Improvecomponent lifespanVSAvoidrecovery time
Core Design Contradiction:
Duration of action of stationary objectVSLoss of time

Solution Approach 1:

The seed laser is kept continuously operating in advance, maintaining the laser medium in a ready state. When imaging begins, only the amplifier unit needs to be activated, which takes minimal time. This preliminary preparation of the seed laser eliminates long recovery times while still allowing the amplifier components to rest during intervals between acquisitions.

Inventive Principle:
Principle #10Preliminary action

Solution Approach 2:

The system dynamically adjusts the operational state of different components based on real-time needs. The seed laser operates continuously while the amplifier unit is dynamically switched on only during imaging acquisitions. This dynamic approach minimizes both component aging and activation time, as the system transitions from a static all-on or all-off state to a flexible, demand-based operational mode.

Inventive Principle:
Principle #15Dynamics

3Object-affected harmful factors

If shutters or modulators are used to block laser light during non-acquisition periods, then component protection is improved, but device complexity increases

Engineering Contradiction:
Improvecomponent protectionVSAvoidsystem complexity
Core Design Contradiction:
Object-affected harmful factorsVSDevice complexity

Solution Approach 1:

The patent extracts the light-blocking function from separate components like shutters or modulators and integrates it directly into the amplifier unit's pump source control. By turning off the pump source, the amplifier naturally blocks light transmission without requiring additional mechanical or optical blocking components. This reduces device complexity while maintaining effective component protection during non-acquisition periods.

Inventive Principle:
Principle #2Taking out (Extraction)

4Power

If the amplifier unit is operated continuously to maintain output power, then laser performance is improved, but energy consumption and component aging increase

Engineering Contradiction:
Improveoutput powerVSAvoidenergy consumption
Core Design Contradiction:
PowerVSUse of energy by moving object

Solution Approach 1:

The amplifier unit operates periodically only during imaging acquisitions rather than continuously. The seed laser maintains continuous operation to ensure immediate availability, but the amplifier is activated in periodic bursts synchronized with imaging needs. This periodic operation significantly reduces energy consumption and component aging while maintaining the required output power during actual imaging periods.

Inventive Principle:
Principle #19Periodic action

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

This approach substantially extends the lifespan of sensitive components by ensuring they are only active during actual image acquisition, maintaining stable operation within a fraction of a second and minimizing aging, thus reducing overall system degradation.

Implementation Method 1

a control system which controls the current of the pump source of the amplifier unit as a function of the output power of the laser light source, in particular with the aid of a monitor photodiode

Methodology Applied
Scientific EffectPhotoelectric Effect: Photoelectric Effect

Implementation Method 2

at least one laser amplifier 15 disposed downstream of the seed laser 12

Methodology Applied
Scientific EffectStimulated Emission: Laser

Implementation Method 3

a pump source 17 associated with the laser amplifier 15 to energize the laser amplifier 15

Methodology Applied
Scientific EffectOptical Pumping: Pump

Data Source

PatentUS8913317B2Method and device for illuminating a sample in a laser microscope
Publication Date: 2014.12.16 LEICA MICROSYSTEMS CMS GMBH
  • US8913317B2 patent drawing
  • US8913317B2 patent drawing
  • US8913317B2 patent drawing

AI summary

The invention relates to a method and a device for illuminating or irradiating an object, a sample (8), or the like, for the purpose of imaging or analysis, particularly for use in a laser microscope (1), preferably in a confocal microscope having a laser light source (2) emitting the illuminating light, the laser light being coupled directly or by means of a glass fiber into an illumination light path (4), characterized in that the laser light source (2) is switched on rapidly upon a trigger signal directly prior to the actual need, for example, directly prior to imaging.