Lateral Flow Assay Test Kit for Rapid SARS-CoV-2 Antigen Detection
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
There is a pressing need for rapid and accurate detection methods and devices to identify SARS-CoV-2 infection and COVID-19 agents, especially during pandemics, to facilitate early treatment and prevent the spread of the infection.
Innovation Solution
A novel lateral flow assay-based test kit that uses nasopharyngeal or nasal swabs to detect SARS-CoV-2 antigens through a dipstick test strip, providing a visual signal for the presence or absence of the infection, allowing for quick and qualitative diagnosis.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If traditional laboratory-based detection methods are used, then measurement precision is improved, but time consumption increases and accessibility decreases
Solution Approach 1:
The patent replaces complex mechanical laboratory equipment with a lateral flow assay system that uses capillary action and visual detection. The test strip utilizes fluid dynamics and antibody-antigen binding to achieve detection without requiring sophisticated mechanical instruments, thereby reducing time and increasing accessibility while maintaining adequate precision.
Solution Approach 2:
The invention extracts the essential detection function from complex laboratory systems and isolates it into a simplified lateral flow assay. By separating the critical detection mechanism (antibody-antigen binding) from unnecessary laboratory infrastructure, the system achieves rapid point-of-care testing without sacrificing fundamental detection accuracy.
2Loss of time
If rapid detection methods are implemented, then time consumption is reduced, but device complexity increases
Solution Approach 1:
The lateral flow assay test strip performs detection automatically through capillary action and visual reading. The sample migrates through the strip autonomously, and the result is read directly without requiring external power sources, instruments, or complex operational procedures. This self-service mechanism achieves rapid detection while minimizing device complexity.
3Ease of operation
If point-of-care testing is deployed, then accessibility is improved, but manufacturing precision requirements increase
Solution Approach 1:
The patent optimizes parameters such as conjugate concentration, antibody affinity, and membrane porosity to ensure reliable detection. By carefully controlling these parameters during manufacturing, the system achieves adequate precision for point-of-care use without requiring extremely tight manufacturing tolerances, thus balancing accessibility with manufacturability.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Enables rapid detection of SARS-CoV-2 antigens within 15 minutes, aiding in early diagnosis and infection control, with the potential for point-of-care use outside traditional laboratories, thereby supporting public health management during outbreaks.
Implementation Method 1
A novel lateral flow assay-based test kit that uses nasopharyngeal or nasal swabs to detect SARS-CoV-2 antigens through a dipstick test strip
Implementation Method 2
lateral flow assay-based test kit that uses nasopharyngeal or nasal swabs to detect SARS-CoV-2 antigens through a dipstick test strip
Data Source
AI summary
Devices, methods and test kits for the detection of coronavirus infection are disclosed. The methods include detecting the presence of coronavirus antigens comprising the use of antibodies bound to nanoparticles immobilized on a solid support chromatographic immunoassay. The devices, methods and test kits include detection of SARS-CoV-2.