Lateral Flow Assay Cartridge Positioning for Quantitative Reading
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Solution Overview
Problem
Current lateral flow chromatographic immunoassay tests are limited to providing qualitative results, lacking the capability to deliver quantitative data, which hinders precise point-of-care diagnostics.
Innovation Solution
A device and system that integrates a digital reader with a lateral flow assay cartridge, allowing for the precise reading of quantitative results through a frame and base plate configuration that positions the cartridge for optimal detection of analytes.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of operation
If lateral flow chromatographic immunoassay tests are used for point-of-care testing, then ease of use and rapid results are improved, but measurement precision and quantitative capability deteriorate
Solution Approach 1:
The patent combines the simple lateral flow assay format with digital imaging technology and image analysis software. The LFA cartridge maintains its ease of use while the integrated digital reader captures images of the test results and software algorithms convert the visual signals into quantitative measurements, thus merging qualitative and quantitative capabilities in one system
Solution Approach 2:
The patent introduces a digital camera and image analysis software as intermediary components between the LFA test strip and the user. The camera captures the test result image, and the software processes the image data to extract quantitative information, serving as a mediator that transforms the simple visual output of LFA into quantifiable data without complicating the basic test procedure
2Productivity
If lateral flow chromatographic immunoassay tests are used at point of care, then accessibility and speed are improved, but diagnostic accuracy and quantitative analysis deteriorate
Solution Approach 1:
The patent replaces manual visual assessment with automated digital imaging and computer-based image analysis. The digital camera captures the test result, and software algorithms automatically process the image to determine quantitative results, substituting human interpretation with automated systems that provide both speed and accuracy
Solution Approach 2:
The patent implements a feedback mechanism where the digital reader captures the test result image, the software analyzes the image to determine the analyte concentration, and the quantitative result is displayed to the user. This closed-loop feedback system ensures accurate interpretation of the test results while maintaining rapid turnaround
Data Source
AI summary
A device for receiving a digital reader and a lateral flow assay (LFA) cartridge and systems incorporating the same are provided. Aspects of the device include a body having a frame configured to receive the digital reader and a base plate having one or more LFA cartridge receiving positions for positioning one or more LFA cartridges at a fixed orientation relative to a planar space defined by the frame. Also provided are methods for using the device to read a result indicative of the presence or absence of an analyte in a sample.