Left Atrial Appendage Occlusion Device with Inverted Anchoring Skirt
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Solution Overview
Problem
Current medical devices fail to effectively occlude the left atrial appendage, leading to thrombus formation and embolic stroke risk due to inadequate contraction during arrhythmias, and existing solutions do not provide sufficient anchoring without tissue trauma.
Innovation Solution
A medical occlusive device with a frame composed of elongate occlusive frame members, a hub member, and a covering component that allows blood passage while preventing emboli, designed for minimally invasive deployment to securely occlude the left atrial appendage without traumatic piercing, featuring a distal portion, laterally facing skirt, and inverted section for enhanced anchoring.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Object-affected harmful factors
If traditional occlusive devices are used to block the left atrial appendage, then emboli passage is prevented, but tissue trauma occurs due to inadequate anchoring mechanisms
Solution Approach 1:
The device divides the anchoring function into multiple independent elements: elongate frame members with laterally facing skirts that engage the appendage wall, and inverted sections with additional anchoring elements. This segmentation allows distributed anchoring forces across multiple contact points, achieving reliable fixation without concentrated tissue trauma.
Solution Approach 2:
The device employs an inverted section that folds back toward the proximal end, creating anchoring surfaces that engage the appendage wall from within. This inverted configuration allows the device to anchor itself using the appendage's own geometry, preventing trauma associated with external piercing or anchoring mechanisms.
2Reliability
If the left atrial appendage is occluded during arrhythmias, then thrombus formation is prevented, but blood flow disturbance persists
Solution Approach 1:
The device incorporates a porous covering component that allows selective passage of blood while blocking thrombus and emboli. The porous structure permits normal blood flow through the occluded appendage, preventing blood stasis and associated flow disturbances while maintaining the occlusive function against pathological particles.
Solution Approach 2:
The device applies different functional properties to different regions: the occlusive face portion provides complete blockage at the ostium to prevent thrombus formation, while the porous covering on the distal portion allows controlled blood flow. This local differentiation of properties resolves the contradiction between effective occlusion and maintenance of physiological flow.
3Object-affected harmful factors
If a covering component is added to prevent emboli passage, then embolic stroke risk is reduced, but device complexity increases
Solution Approach 1:
The porous covering component is integrated directly onto the frame structure, merging the occlusive function with the structural support function. This integration eliminates the need for separate covering components or additional anchoring devices, reducing overall device complexity while maintaining embolic protection.
Solution Approach 2:
The frame members serve multiple functions simultaneously: providing structural support, creating anchoring surfaces through lateral skirts, forming the occlusive face, and supporting the porous covering. This multi-functionality reduces the number of separate components needed, simplifying the overall device design while achieving embolic stroke prevention.
Data Source
Figure 1A
Figure 1B
Figure 1C
AI summary
A device frame includes a plurality of elongate frame members (102), first and second hub members (108, 116) substantially aligned along a longitudinal axis of the device frame, and a coupling element (689) that couples the first hub member to the second hub member. The device frame includes a face section (110), a laterally facing skirt section (112), and an inverted section (114). First portions of the elongate members define the face section and extend radially from the first hub member. Second portions of the elongate members define the laterally facing skirt section and extend in a distal, axial, and helical direction along a first rotational direction from the face section. Third portions of the elongate members define the inverted section and extend in a generally proximal direction from a distal portion of the laterally facing skirt section to the second hub member along a rotational direction opposite the first rotational direction.