Lavender Eucalyptus Composition for Skin Gene Expression
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Current methods fail to effectively enhance the expression of clock genes and hyaluronic acid synthase genes, which are crucial for regulating circadian rhythms and skin health, leading to potential skin issues and diseases.
Innovation Solution
A composition combining lavender oil and eucalyptus oil with an alkylene oxide derivative is used to promote the expression of clock genes like Bmal and Period, and hyaluronic acid synthase genes, thereby regulating skin circadian rhythms and increasing hyaluronic acid production for improved skin health.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If a plant extract is used to promote expression of clock gene and hyaluronic acid synthase gene, then gene expression is enhanced, but the effectiveness is insufficient
Solution Approach 1:
The patent combines lavender oil and eucalyptus oil in a specific composition to achieve synergistic effects. Lavender oil promotes clock gene expression while eucalyptus oil promotes hyaluronic acid synthase gene expression, and their combination provides comprehensive gene expression enhancement that neither component achieves alone, resolving the insufficiency of single plant extracts
Solution Approach 2:
The invention creates a composite composition containing multiple plant extracts (lavender oil, eucalyptus oil) and other ingredients working together. This composite approach allows the formulation to simultaneously target multiple genes (clock gene, PER gene, hyaluronic acid synthase gene) and achieve more effective and reliable gene expression promotion than individual extracts
2Stability of the object's composition
If clock gene expression is not sufficiently maintained, then circadian rhythm control is disrupted, but increasing expression requires complex interventions
Solution Approach 1:
The composition enables the skin to self-regulate its circadian rhythm through topical application. The plant extracts in the composition directly promote endogenous gene expression in skin cells, allowing the skin's own biological clock to function properly without requiring complex external circadian rhythm control systems or interventions
Solution Approach 2:
The invention changes the chemical parameters of the skin environment by introducing specific plant extracts that directly interact with gene expression mechanisms. This simple chemical intervention (topical application of the composition) effectively modulates gene expression levels and stabilizes circadian rhythm without complex physical or biological systems
3Productivity
If hyaluronic acid metabolism is slow, then skin health deteriorates, but accelerating metabolism requires multiple components
Solution Approach 1:
The patent extracts and utilizes the specific active components from natural plant sources (lavender oil, eucalyptus oil) that have proven abilities to promote gene expression. By isolating and combining these specific plant extracts, the invention achieves accelerated hyaluronic acid metabolism and improved skin health through a focused, natural composition rather than complex synthetic formulations
Data Source
Figure 1A~1C
Figure 2A~2B
Figure 3A~3C
AI summary
To further effectively promote expression of a clock gene and a hyaluronic acid synthase gene in skin. A composition comprising one kind or two kinds selected from lavender oil and eucalyptus oil, and an alkylene oxide derivative represented by general formula (I) is applied onto skin: R1O-[(AO)m(EO)n]-R2 (I) (wherein, AO represents an oxyalkylene group having 3-4 carbon atoms; EO represents an oxyethylene group; m and n independently represent an average number of moles of the oxyalkylene group having 3-4 carbon atoms added and the oxyethylene group added, respectively, and satisfy expressions: 1 ≤ m ≤ 70 and 1 ≤ n ≤ 70, wherein a ratio of the oxyethylene group to a total of the oxyalkylene group and the oxyethylene group is 20-80 mass%. The oxyalkylene group and the oxyethylene group may be added in a block form or random form. R1 and R2 may be the same or different, and independently represent a hydrocarbon group having 1-4 carbon atoms or a hydrogen atom, wherein a ratio of number of hydrogen atoms to number of hydrocarbon groups in R1 and R2 is 0.15 or less).