Layered Cannabinoid Chewing Gum for Release and Sensorics
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Solution Overview
Problem
Existing chewing gum formulations for delivering cannabinoids face challenges with compromised sensorics characteristics, such as texture and flavor perception, and inadequate release profiles, leading to adverse side effects and difficulty in managing cannabinoid administration.
Innovation Solution
A tableted chewing gum composition with a layered structure, comprising a first layer of water-insoluble gum base and a second layer of water-soluble ingredients, allows for improved release and sensorics properties by separating cannabinoids into distinct layers.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of operation
If water-soluble chewing gum ingredients are present in relatively high amounts, then sweetness perception and texture are improved, but sensorics characteristics are compromised and controlled release of cannabinoids is difficult to achieve
Solution Approach 1:
The chewing gum is divided into two distinct layers: a first layer containing water-insoluble gum base and cannabinoids, and a second layer containing water-soluble chewing gum ingredients. This segmentation allows each layer to independently fulfill its function - the first layer provides controlled cannabinoid release while the second layer provides improved sensorics characteristics including sweetness perception and texture.
Solution Approach 2:
Different regions of the chewing gum (layers) are assigned different compositions and properties. The first layer is designed with water-insoluble characteristics for controlled release, while the second layer is designed with water-soluble characteristics for improved sensorics. This local differentiation resolves the contradiction by allowing each property to excel in its designated region.
2Duration of action of moving object
If conventional chewing gum composition is used, then prolonged release of cannabinoids is achieved, but high release of cannabinoids is not allowed
Solution Approach 1:
The two-layer structure enables differentiated release kinetics - the water-insoluble first layer provides prolonged release over time, while the water-soluble second layer enables rapid initial release. This segmentation resolves the contradiction between prolonged and high release by allowing both to occur through different mechanisms in different layers.
Solution Approach 2:
The chewing gum combines water-insoluble and water-soluble materials in a layered composite structure. This composite approach allows the system to exhibit both prolonged release characteristics (from the water-insoluble layer) and high release capability (from the water-soluble layer), resolving the contradiction between these opposing release profiles.
3Quantity of substance
If cannabinoids are delivered at higher amounts, then therapeutic effect is improved, but off-notes become predominant and saliva production is suppressed
Solution Approach 1:
The water-soluble second layer acts as an intermediary between the cannabinoid-containing first layer and the user's oral environment. This intermediary layer masks the off-notes associated with cannabinoids while allowing controlled delivery of the cannabinoids themselves, thereby enabling higher cannabinoid delivery without the harmful side effects becoming predominant.
Solution Approach 2:
The invention converts the potentially harmful off-notes and adverse effects into a benefit by using the water-soluble second layer to mask these negative sensations. This allows the system to deliver higher amounts of cannabinoids therapeutically while the water-soluble layer absorbs or masks the harmful sensory effects, turning a disadvantage into an advantage.
Data Source
AI summary
A tableted chewing gum composition for oral administration of cannabinoids includes a plurality of particles, including a first population of particles having water-insoluble gum base and a second population of particles having water-soluble chewing gum ingredients. The composition constitutes at least two layers, where a first layer of the composition has water-insoluble gum base and a second layer of the composition, which is cohered to and adjacent to the first layer, has water-soluble chewing gum ingredients. The second layer is free of water-insoluble gum base, and the composition includes one or more cannabinoids.

