Layered Detection Substrate for Integrated Biofluorescence Sensing
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Solution Overview
Problem
Conventional biomolecular microarray chips lack integrated fluorescence reaction detection capabilities, necessitating separate devices for biological and fluorescence reactions, hindering rapid and simultaneous detection of multiple samples.
Innovation Solution
A detection substrate and circuit incorporating inorganic and organic transistors, along with a photoelectric sensor element, allowing for integrated biological and fluorescence reaction detection by arranging the organic transistor and photoelectric sensor element in specific film layers to avoid performance degradation from high-temperature fabrication processes.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Adaptability or versatility
If conventional biomolecular microarray chips are used for biological reaction detection, then biological signal detection is achieved, but fluorescence reaction detection capability is lost
Solution Approach 1:
The patent combines biological reaction detection (via organic transistor) and fluorescence reaction detection (via photoelectric sensor element) into a single integrated detection unit on the substrate, eliminating the need for separate detection devices and achieving multi-functional integration
Solution Approach 2:
The detection substrate is designed to perform multiple detection functions simultaneously - it can detect both biological reactions through the organic transistor and fluorescence reactions through the photoelectric sensor element, making the device universal for different types of reactions
2Area of stationary object
If photoelectric sensor element is placed close to substrate for compact design, then device area is reduced, but high-temperature fabrication degrades sensor performance
Solution Approach 1:
The patent resolves the conflict by moving the photoelectric sensor element from the substrate plane to a different vertical layer (film layer), allowing compact integration while maintaining sufficient distance from high-temperature processing zones to preserve sensor performance
Solution Approach 2:
The detection unit is designed with nested layering where the photoelectric sensor element is positioned in a film layer above the substrate, nested within the overall device structure but spatially separated from the substrate to avoid thermal damage during fabrication
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Enables simultaneous detection of biological and fluorescence reactions on a single substrate, enhancing detection efficiency and accuracy while reducing the need for separate devices.
Implementation Method 1
Each detection unit includes at least an inorganic transistor, an organic transistor, and a photoelectric sensor element
Data Source
AI summary
A detection substrate including a substrate and a plurality of detection units disposed on a side of the substrate, each detection unit including at least an inorganic transistor, an organic transistor, and a photoelectric sensor element, the organic transistor including an organic semiconductor part, in a direction perpendicular to a plane of the substrate, a film layer where the organic semiconductor part is located being located on the side of the film layer where the inorganic transistor is located away from the substrate, the film layer where the organic semiconductor part is located being located on the side of a film layer where the photoelectric sensor element is located away from the substrate, the organic transistor of the detection unit being connected to a sensing electrode, the sensing electrode being located on the side of the film layer where the inorganic transistor is located away from the substrate.