Layered Embolic Sealing Structure to Prevent Migration
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Solution Overview
Problem
Liquid embolic agents used for vascular treatments face challenges with migration out of the treatment site, limiting their application to specific conditions due to the risk of embolic migration.
Innovation Solution
A sealing device with multiple layers, including a denser inner and looser outer mesh, is used to trap liquid embolic between the layers, preventing migration by expanding to seal the treatment site.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If liquid embolic is used for vascular treatment, then occlusive advantages are improved, but embolic migration risk increases
Solution Approach 1:
A sealing device acts as an intermediary between the liquid embolic and the vascular system. The device is deployed at the treatment site to contain the liquid embolic, preventing its migration while allowing it to perform its occlusive function. The sealing device serves as a mediator that enables the use of liquid embolic by mitigating its harmful migration tendency.
Solution Approach 2:
The sealing device employs flexible mesh structures that can conform to the vascular anatomy at the treatment site. These flexible shells create a containment barrier that prevents liquid embolic migration while maintaining adaptability to the vascular environment, thus resolving the contradiction between occlusive effectiveness and migration prevention.
2Object-affected harmful factors
If liquid embolic is contained within treatment site, then embolic migration is prevented, but application scope is limited
Solution Approach 1:
The sealing device is designed with multi-functionality to be applicable across various vascular conditions. By providing a universal containment mechanism that can be deployed at different treatment sites, the device enables liquid embolic to be used for a broader range of conditions including aneurysms and arteriovenous malformations, thus expanding application scope while maintaining migration prevention.
Solution Approach 2:
The sealing device allows for parameter changes in terms of deployment location and configuration to adapt to different vascular conditions. By modifying the deployment parameters rather than the fundamental containment mechanism, the system maintains effective migration prevention while expanding versatility across different treatment scenarios.
3Object-affected harmful factors
If multiple layer structure is used to trap liquid embolic, then migration containment is improved, but device complexity increases
Solution Approach 1:
The sealing device is segmented into multiple layers with different mesh densities. The outer layer has a looser mesh structure while the inner layer has a denser mesh structure, creating a gradient containment system. This segmentation allows effective liquid embolic trapping through the layered structure while maintaining relative simplicity through modular design principles.
Solution Approach 2:
Different layers of the sealing device have locally optimized mesh densities tailored to their specific functions. The outer layer provides initial containment with looser mesh, while the inner layer provides secondary containment with denser mesh. This local quality optimization achieves effective containment without requiring uniform complexity throughout the entire device structure.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The sealing device effectively contains liquid embolic within aneurysms and AVMs, allowing for broader use of liquid embolic agents in various vascular conditions.
Implementation Method 1
Liquid embolic, while offering some occlusive advantages, can be difficult to use since there is a high risk of the liquid embolic migrating out of the treatment site. Liquid embolic is part of a newer class of compounds and are a type of biocompatible liquid which precipitates upon exposure to blood to harden and occlude a treatment site.
Data Source
AI summary
Devices, systems, and methods used to seal a treatment area to prevent embolic agents from migrating are described. The concept has particular benefit in allowing liquid embolic to be used with a variety of intravascular therapeutic applications, including for occluding aneurysms and arteriovenous malformations in the neurovasculature.