Layered Embolic Sealing Device to Prevent Migration
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Solution Overview
Problem
Liquid embolic agents used for vascular treatments face a high risk of migration, limiting their application to specific conditions due to the inability to effectively seal the treatment site, particularly in aneurysms and arteriovenous malformations.
Innovation Solution
A sealing device with multiple layers, including a denser inner and looser outer mesh, is deployed to trap liquid embolic within the treatment area, utilizing a core wire for shape control and expansion to prevent migration, and can be delivered via a pusher system.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If liquid embolic is used for vascular treatment, then occlusive advantages are achieved, but high risk of migration occurs
Solution Approach 1:
The sealing device acts as an intermediary structure between the liquid embolic and the vascular system. It provides a physical barrier that contains the liquid embolic within the treatment site while allowing controlled delivery, thereby preventing migration while maintaining occlusive effectiveness.
Solution Approach 2:
The sealing device utilizes a flexible mesh structure that can conform to the treatment site geometry. This flexible shell configuration allows the device to adapt to irregular vascular structures while maintaining containment, preventing liquid embolic migration through its mesh architecture.
2Object-affected harmful factors
If sealing device with multiple layers is deployed, then liquid embolic containment is improved, but device complexity increases
Solution Approach 1:
The sealing device is segmented into multiple layers with different mesh densities. The outer layer has a looser mesh for initial containment, while the inner layer has a denser mesh for secure trapping of liquid embolic. This segmentation allows each layer to perform its specific function, improving overall containment while maintaining manageable device complexity.
Solution Approach 2:
Different regions of the sealing device have different mesh densities tailored to local requirements. The outer layer uses a looser mesh structure for initial containment and flexibility, while the inner layer uses a denser mesh for secure embolic trapping. This local differentiation of structural properties optimizes containment effectiveness without uniformly increasing complexity throughout the entire device.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The sealing device effectively contains liquid embolic within aneurysms and AVMs, allowing broader use of liquid embolic agents across various vascular conditions by preventing migration and ensuring occlusion.
Implementation Method 1
Liquid embolic is part of a newer class of compounds and are a type of biocompatible liquid which precipitates upon exposure to blood to harden and occlude a treatment site.
Data Source
AI summary
Devices, systems, and methods used to seal a treatment area to prevent embolic agents from migrating are described. The concept has particular benefit in allowing liquid embolic to be used with a variety of intravascular therapeutic applications, including for occluding aneurysms and arteriovenous malformations in the neurovasculature.