Liquid Chromatography Thermal Chamber Ice Detection

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Solution Overview

Problem

Liquid chromatography thermal systems face challenges in maintaining accurate temperature control within thermal chambers, particularly at or near the freezing point of water, due to issues like ice buildup and unexpected engine failures.

Innovation Solution

A method and system for determining the status of a thermal chamber in liquid chromatography systems, involving the use of temperature sensors and power monitoring to assess the efficiency of the temperature control engine and detect ice formation on the heat sink.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Temperature

If a heat sink runs at temperatures below 0°C to control the thermal chamber temperature, then the temperature control precision is improved, but ice builds up on the heat sink which reduces engine performance and causes temperature control failure

Engineering Contradiction:
Improvethermal chamber temperature control precisionVSAvoidengine performance reliability
Core Design Contradiction:
TemperatureVSReliability

Solution Approach 1:

The system performs preliminary heating of the heat sink before ice buildup occurs by detecting temperature trends and proactively adjusting the cooling power, preventing ice formation before it degrades engine performance

Inventive Principle:
Principle #10Preliminary action

Solution Approach 2:

The system uses temperature sensors to continuously monitor the thermal chamber temperature and heat sink temperature, feeding this information back to the control system which adjusts the cooling power dynamically to maintain optimal temperature without causing ice buildup

Inventive Principle:
Principle #23Feedback

2Stability of the object's composition

If the temperature control engine operates continuously to maintain precise temperature, then temperature stability is improved, but the risk of unexpected engine failure increases

Engineering Contradiction:
Improvetemperature stabilityVSAvoidengine failure risk
Core Design Contradiction:
Stability of the object's compositionVSReliability

Solution Approach 1:

The system performs preliminary assessment of engine health by monitoring temperature control efficiency and detecting deviations from expected performance patterns, enabling early warning of potential engine failures before they occur

Inventive Principle:
Principle #10Preliminary action

Solution Approach 2:

The system monitors its own operational status and temperature control efficiency, automatically detecting when the engine performance degrades and alerting users to potential failures without external intervention

Inventive Principle:
Principle #25Self-service

3Measurement precision

If temperature sensors and power monitoring are added to detect thermal status, then the detection accuracy is improved, but the device complexity increases

Engineering Contradiction:
Improvethermal status detection accuracyVSAvoidsystem component quantity
Core Design Contradiction:
Measurement precisionVSDevice complexity

Solution Approach 1:

The system uses existing temperature sensors originally intended for basic temperature control and makes them serve multiple functions including ice detection, engine health monitoring, and predictive maintenance by analyzing temperature patterns and power consumption

Inventive Principle:
Principle #6Universality (Multi-functionality)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The solution effectively maintains precise temperature control, prevents ice buildup, and predicts potential engine failures, thereby ensuring the reliability and performance of liquid chromatography systems.

Implementation Method 1

receiving, by a computer system, a first temperature measurement from a first temperature sensor configured to sense a temperature of a heat sink

Methodology Applied
Scientific EffectTemperature sensing: Thermocouple

Implementation Method 2

receiving, by the computer system, a second temperature measurement from a second temperature sensor configured to sense a temperature of the thermal chamber

Methodology Applied
Scientific EffectTemperature sensing: Thermocouple

Implementation Method 3

power information related to power utilized by a temperature control engine configured to maintain the temperature of the thermal chamber

Methodology Applied
Scientific EffectHeat transfer: Heat Exchanger

Data Source

PatentEP3824281B1Liquid chromatography thermal system with thermal status detection
Publication Date: 2025.06.11 WATERS TECHNOLOGY CORP
  • EP3824281B1 patent drawingFigure 1
  • EP3824281B1 patent drawingFigure 2
  • EP3824281B1 patent drawingFigure 3

AI summary

A device and a method for determining a status of a thermal chamber in a liquid chromatography system. The method (200) includes a step (210) of monitoring the temperature of a heat sink, a thermal chamber and/or an ambient temperature outside the thermal chamber. A step (212) sends these temperature measurements made by the sensors (110,111,112) to a computer system (120). The method (200) includes another step (220) of monitoring the power use of a heater/cooler engine, and sending (222) power information to the computer system (120). The method steps (210) and (212) may be occurring simultaneous to the method steps (220), (222) in one embodiment. The method (200) further includes a step (230) of receiving the temperature measurements and the power information generated or taken by the sensors from the steps (210), (212), (220), and (222), by the computer system. A next step (232) analyzes the temperature measurements, information, data or the like that is received and determines (234) a status, such as whether ice has formed on a heat sink of the system.