Layered Double Hydroxide Fluoride Delivery System
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Solution Overview
Problem
Current fluoride delivery systems in dentistry often provide only short-term benefits and can lead to excessive fluoride exposure, causing dental fluorosis and surface re-mineralization issues, with few products capable of sustained low-level fluoride delivery and rechargeability.
Innovation Solution
A dental composition incorporating a rechargeable fluoride delivery system based on layered double hydroxides (LDHs) that can uptake and re-release fluoride, providing a sustained low-level fluoride release without the need for high concentrations, suitable for use in various dental applications.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If high concentration fluoride products (gels and varnishes) are used to prolong fluoride exposure, then caries protection is improved, but dental fluorosis and surface re-mineralization issues occur
Solution Approach 1:
The patent changes the concentration parameter from high to low levels of fluoride release. The layered double hydroxide system releases fluoride at low concentrations over extended periods, maintaining caries protection while avoiding the harmful effects of high concentration fluoride exposure such as dental fluorosis and surface re-mineralization issues
Solution Approach 2:
The patent implements continuous fluoride release through the layered double hydroxide system that can be recharged. The system provides sustained low-level fluoride delivery over time, maintaining protective action continuously without the need for repeated high-concentration applications that cause harm
2Duration of action of moving object
If most fluoride-containing products are used, then short-term caries protection is achieved, but sustained low-level fluoride delivery is not provided
Solution Approach 1:
The layered double hydroxide system provides continuous fluoride release over extended periods. The rechargeable mechanism allows the system to be recharged and continue delivering fluoride at low levels consistently, achieving both prolonged duration and reliable caries protection
Solution Approach 2:
The system is designed to be rechargeable, where the layered double hydroxide can be recharged with fluoride. This self-service capability allows the system to replenish its fluoride supply and continue providing sustained protection without external intervention, maintaining both duration and reliability
3Reliability
If glass ionomer cements are used for fluoride release, then fluoride uptake and re-release capability is achieved, but limited capacity for fluoride storage is present
Solution Approach 1:
The layered double hydroxide structure utilizes its porous interlayer structure to store and release fluoride ions. The porous nature of the LDH material provides high surface area and capacity for fluoride uptake and controlled release, overcoming the limited capacity of glass ionomer cements
Solution Approach 2:
The patent employs composite material strategies by combining layered double hydroxide with appropriate carriers or matrices. This composite approach enhances the fluoride storage capacity while maintaining the rechargeable and controlled release properties, surpassing the limitations of glass ionomer cements
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The LDH-based system maintains optimal fluoride levels in the oral cavity, preventing caries effectively while avoiding excessive fluoride exposure, offering a prolonged and controlled release of fluoride, enhancing cariostatic effects and reducing the risk of fluorosis.
Implementation Method 1
LDHs have a very strong affinity for fluoride. For example, hydroxyapatite (Ca 5 (PO 4 ) 3 OH) readily exchanges its hydroxyl ion for a fluoride ion to form fluorapatite (Ca 5 (PO 4 ) 3 F)
Implementation Method 2
the fluoride ion is not released readily
Data Source
Figure 1~2
Figure 3~4
Figure 5~6
AI summary
The present invention provides dental compositions and devices comprising a rechargeable fluoride5 delivery system wherein the rechargeable fluoride delivery system comprises a layered double hydroxide with the formula M(II)1-x M(III)x (OH)2 (An-)x/n yH20 where M(II) is a divalent cation, M(III) is a trivalent cation, A is an anion with a charge, x is a value between 0.2 and 0.33, y is an integer between 1 and 10 and n has a value of 1.