LDH Modifier System for Anion Release Control
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Solution Overview
Problem
Current compositions fail to effectively control the release and solubility of active anions from layered double hydroxide (LDH) materials, particularly in acidic media, which is crucial for pharmaceutical and nutraceutical applications, especially for poorly water-soluble drugs like ibuprofen, as they either release too little or too much of the active ingredient, affecting absorption rates.
Innovation Solution
A composition comprising LDH-active anion materials intercalated with one or more active anions, combined with a modifier system of surfactants and pharmaceutically acceptable salts, which controls the release and solubility of the active anion in acidic media, allowing for either increased or decreased absorption rates by adjusting the amount and solubility of the active anion.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If LDH-active anion materials are used to control release of active anion, then release control is improved, but solubility control in acidic media is insufficient
Solution Approach 1:
The patent introduces a modifier system comprising surfactants and pharmaceutically acceptable salts as intermediary substances that mediate between the LDH-active anion material and the acidic gastric environment. The surfactants (e.g., polysorbates, polyoxyl ethers) and salts (e.g., sodium citrate, calcium carbonate) work together to enhance the solubility of released active anions in acidic media while maintaining controlled release from the LDH structure, thereby resolving the contradiction between release control and solubility control
2Quantity of substance
If more surfactant is added to increase solubility of active anion, then solubility is improved, but formulation complexity and cost increase
Solution Approach 1:
The patent combines multiple functional components (surfactants and pharmaceutically acceptable salts) into a single integrated modifier system that performs multiple functions simultaneously: enhancing solubility, controlling release, and improving stability. This merging approach avoids the need for separate solubilization and release control mechanisms, thereby reducing overall formulation complexity while achieving the desired solubility enhancement
Solution Approach 2:
The patent optimizes the concentrations and types of surfactants and salts in the modifier system to achieve effective solubility enhancement at reasonable levels. By carefully selecting parameters such as surfactant concentration, chain length, and salt composition, the formulation achieves optimal solubility without excessive complexity or cost
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The combination of surfactants and salts in the modifier system significantly enhances or reduces the release and solubility of active anions, providing flexibility in absorption rates, reducing surfactant amounts, and improving formulation stability and palatability, while maintaining effective drug delivery.
Implementation Method 1
control release of the intercalated active anion from the layers of the LDH structure
Implementation Method 2
a modifier system comprising a) one or more surfactants, in combination with b) one or more pharmaceutically acceptable salts
Data Source
AI summary
The invention relates to a composition comprising: i) one or more LDH-active anion materials comprising an LDH matrix intercalated with one or more active anions, and ii) a modifier system comprising a) one or more surfactants, in combination with b) one or more compounds having the generic formula MA, where M comprises one or more positively charged ions and A comprises one or more negatively charged counter ions.