Lecithin Composition for Psoriasis Treatment
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Solution Overview
Problem
Current treatments for psoriasis and dermatoses, such as corticosteroids and phototherapy, have significant limitations including side effects, restricted usage, and uncertain effectiveness, failing to provide long-term solutions for patients with extensive or chronic conditions.
Innovation Solution
A lecithin-based composition, particularly marine lecithin rich in phospholipids esterified with omega3 fatty acids, is used in a therapeutic formulation for topical or oral administration to treat abnormal keratotic and squamous formations of the dermis, offering a side-effect-free and convenient treatment option.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If cortisone-based lotions and vitamin D derivatives are used for treating psoriasis, then symptomatic relief is achieved, but the results are only transient and side effects occur such as skin atrophy and disease rebound
Solution Approach 1:
The patent changes the chemical composition parameter by using lecithin (phospholipids) instead of corticosteroids and vitamin D derivatives. This substitution fundamentally alters the therapeutic mechanism from hormonal/receptor-based action to a membrane-stabilizing and anti-inflammatory action through phospholipid incorporation into skin cell membranes, thereby achieving sustained therapeutic effect without the harmful side effects of conventional treatments
Solution Approach 2:
The patent employs lecithin, a naturally occurring substance found in many foods and supplements, replacing expensive and potentially harmful pharmaceutical compounds. Lecithin is safe, non-toxic, and can be used long-term without accumulation of harmful effects, making it a sustainable alternative to conventional psoriasis treatments
2Reliability
If phototherapy sessions with UVB or UVA rays are conducted to treat psoriasis, then curing results are achieved, but long-term induction of skin cancers and accelerated aging occurs
Solution Approach 1:
The patent converts the approach by using substances that strengthen skin defenses against UV damage rather than relying on UV exposure itself. Lecithin and omega-3 fatty acids enhance skin barrier function and reduce inflammation, providing protective benefits that counteract the harmful effects of UV radiation while maintaining therapeutic effectiveness
Solution Approach 2:
Instead of using UV radiation to treat psoriasis (which causes skin damage), the patent inverts the approach by applying topical substances that protect and heal skin while reducing inflammation. This reverses the treatment paradigm from damaging then healing to healing without damage, eliminating cancer risk while maintaining efficacy
3Reliability
If retinoids are used orally in combination with phototherapy or methotrexate to treat severe psoriasis, then therapeutic effect is improved, but hematological and hepatic side effects occur requiring close monitoring
Solution Approach 1:
The patent replaces toxic systemic medications with safe topical lecithin application. Lecithin is a naturally occurring phospholipid that is non-toxic and does not accumulate in the body to harmful levels, eliminating the need for blood monitoring and liver function tests required with conventional systemic treatments
Solution Approach 2:
The patent uses lecithin as an intermediary substance that delivers therapeutic effects locally to the skin without entering systemic circulation in harmful amounts. The phospholipids act as mediators that reduce inflammation and normalize skin cell turnover through localized membrane stabilization, avoiding the systemic toxicity of oral retinoids and methotrexate
Data Source
AI summary
The invention relates to the use of lecithin or of an extract rich in lecithin for preparing a pharmaceutical composition that is useful in the prevention and therapeutic treatment of new or previous dermatites, particularly psoriasis. The invention also relates to therapeutic compositions containing lecithin or an extract rich in lecithin. According to one advantageous characteristic, the phospholipids that compose the lecithin are esterified by omega-3 polyunsaturated fatty acids, in particular, by docosahexaenoic acid (DHA), eicosapentaenoic acid (EPA), docosapentaenoic acid (DPA) or by an alkyl glycerol. The lecithin can be a marine lecithin , i.e. an extract of a marine organism selected among fish, shrimp, krill, zooplankton, algae, phytoplankton or a mixture thereof, of which the advantage resides in the fact that its phospholipids, particularly the phosphatidylcholine, are naturally esterified by omega-3 fatty acids, and essentially by DHA and EPA.