LED Light Irradiation for Genetic Material Deformation Analysis
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Solution Overview
Problem
Existing cancer diagnosis methods are costly and time-consuming, requiring multiple examinations such as angiography, CT, ultrasound, MRI, endoscope, immunological, and pathological examinations.
Innovation Solution
A light irradiation apparatus that cuts genetic material into sections of different sizes using light of specific wavelengths, deforms it to varying degrees, and analyzes the deformation to distinguish between normal and abnormal samples, with a cytotoxicity value greater than or equal to a predetermined value, using a LED as a light source to minimize sample damage and enhance accuracy.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If multiple examinations (angiography, CT, ultrasound, MRI, endoscope, immunological, and pathological examinations) are conducted to diagnose cancer, then diagnostic accuracy is improved, but examination time and cost increase
Solution Approach 1:
The patent extracts and isolates specific genetic material markers (such as circulating tumor DNA or specific gene mutations) from complex biological samples. By focusing on these extracted markers rather than conducting comprehensive multiple examinations, the system achieves accurate cancer diagnosis through targeted analysis of deformation patterns in specific genetic sequences, significantly reducing examination time while maintaining diagnostic accuracy
Solution Approach 2:
The patent changes the measurement parameter from observing multiple physiological and anatomical parameters (requiring multiple examinations) to measuring the deformation degree of genetic material under light irradiation. This parameter transformation allows cancer detection through a single examination by detecting characteristic deformation patterns of tumor-derived genetic material, thereby reducing both time and cost
2Measurement precision
If light irradiation is increased to enhance cancer detection accuracy, then measurement precision is improved, but cytotoxicity to normal cells increases
Solution Approach 1:
The patent applies light irradiation with specific wavelength characteristics that are selectively absorbed by photosensitive materials present in abnormal cells but not in normal cells. This local quality approach ensures that the harmful phototoxic effect is concentrated on target cells (cancer cells containing specific photosensitive markers) while sparing normal cells, thereby improving detection accuracy without causing excessive cytotoxicity
Solution Approach 2:
The patent uses the deformation pattern of genetic material as a signature or copy of cancer presence. By analyzing the characteristic deformation pattern rather than directly measuring cell viability or using high-intensity light that causes cytotoxicity, the system achieves accurate cancer detection through pattern recognition, maintaining measurement precision while minimizing harmful effects
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
Enables accurate and cost-effective cancer diagnosis by distinguishing between normal and abnormal samples through genetic material deformation analysis, reducing examination time and complexity.
Implementation Method 1
When the light is applied to the sample, the light may be transmitted into the sample to stimulate a photosensitive material in the sample, and thus, provided in a wavelength band in which reactive oxygen species are generated.
Data Source
AI summary
A light irradiation device including an injection unit to inject a sample, and a light source to apply light to the sample to identify an abnormal cell in the sample, the light source including a substrate and a light emitter including a light emitting diode, in which the light emitted is to cut a genetic material in the sample into sections of different sizes, and to deform the genetic material to different degrees, such that a determination of an abnormality of the sample is based on the degree of deformation, and an irradiation amount or intensity of the light is at an intensity in which a cytotoxicity value of the sample is greater than or equal to a predetermined value, and a ratio of a degree of deformation of the genetic material of the normal sample to that of the abnormal sample is set to be a minimum value.