Legume Protein Protease Composition for Blood Glucose Stabilization

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Solution Overview

Problem

Existing methods for controlling blood glucose levels, such as dietary management and insulin therapy, face significant barriers including treatment adherence, financial burden, and patient-related factors, leading to substantial health and economic burdens.

Innovation Solution

The use of legume proteins, particularly pea protein, combined with an S53 family protease like pro-Kumamolisin, to modulate protein digestion patterns and produce bioactive peptides that lower blood glucose levels.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If dietary sugar intake is controlled to manage blood glucose levels, then blood glucose control is improved, but treatment complexity and patient adherence difficulty increase

Engineering Contradiction:

Improveblood glucose controlVSAvoidtreatment complexity

Core Design Contradiction:

ReliabilityVSDevice complexity

Solution Approach 1:

The patent introduces an enzyme composition as an intermediary substance that facilitates blood glucose control without requiring direct patient intervention in dietary management. The enzyme composition acts as a mediator between food intake and blood glucose levels, simplifying the treatment approach while maintaining effectiveness.

Inventive Principle:

Principle #24Intermediary (Mediator)

2Reliability

If insulin medication is used to control blood glucose levels, then blood glucose control is improved, but financial burden and access barriers increase

Engineering Contradiction:

Improveblood glucose controlVSAvoidfinancial burden

Core Design Contradiction:

ReliabilityVSEase of manufacture

Solution Approach 1:

The patent employs an enzyme composition that can be administered in single-use formulations or short-duration regimens, replacing expensive long-term insulin therapy. The enzyme preparation is designed to be cost-effective and accessible, providing temporary but effective blood glucose control without the ongoing financial burden of insulin medication.

Inventive Principle:

Principle #27Cheap short-living objects (Disposable)

3Reliability

If complex treatment interventions are implemented to manage blood glucose, then blood glucose control is improved, but treatment adherence decreases

Engineering Contradiction:

Improveblood glucose controlVSAvoidtreatment adherence

Core Design Contradiction:

ReliabilityVSEase of operation

Solution Approach 1:

The enzyme composition is designed to work autonomously within the body after administration, requiring minimal patient monitoring or adjustment. The treatment essentially serves itself by directly enzymatically processing carbohydrates in the digestive system, eliminating the need for complex patient education, food labeling analysis, or insulin dosage adjustments that plague current treatments.

Inventive Principle:

Principle #25Self-service

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

This approach effectively decreases and stabilizes blood glucose levels by inducing anti-diabetic effects and reducing the glycemic index of foodstuffs, providing a simpler and potentially more cost-effective alternative to traditional treatments.

Implementation Method 1

The use of legume proteins, particularly pea protein, combined with an S53 family protease like pro-Kumamolisin, to modulate protein digestion patterns and produce bioactive peptides

Methodology Applied

Scientific EffectProteolysis: Hydrolysis

Data Source

PatentUS12516306B2Blood glucose stabilizing methods and compositions

Publication Date: 2026.01.06 DIGESTIVA INC

AI summary

Provided and described herein are methods and compositions for decreasing blood glucose, reducing an increase in blood glucose, and/or lowering the glycemic index of a foodstuff.