Contact Lens Solution Composition for Hyaluronic Acid Sterilization Stability
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Solution Overview
Problem
Contact lenses become soiled with contaminants such as proteins, lipids, and other materials, affecting visual acuity and patient comfort, and hyaluronic acid is sensitive to common sterilization methods like heat sterilization, leading to molecular weight loss and degradation.
Innovation Solution
A contact lens treating solution formulated with hyaluronic acid, erythritol, nonionic surfactants, sodium chloride, potassium chloride, and buffers, which improves stability and reduces molecular weight loss during sterilization, enhancing viscosity and shelf life.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If common heat sterilization methods are used on hyaluronic acid, then sterilization is achieved, but molecular weight loss and degradation occur
Solution Approach 1:
The patent changes the sterilization parameters from high-temperature heat sterilization to lower-temperature methods such as filtration sterilization (0.22 micrometer filters) or autoclaving at reduced temperatures. This parameter change allows sterilization to be achieved while preserving the molecular weight and composition of hyaluronic acid, resolving the contradiction between sterilization efficacy and compositional stability
Solution Approach 2:
The patent replaces the thermal sterilization mechanism with alternative sterilization mechanisms such as filtration (physical barrier method) or lower-temperature autoclaving. This substitution eliminates the harmful thermal effects that cause hyaluronic acid degradation while maintaining sterilization effectiveness
2Object-generated harmful factors
If contact lenses are cleaned with conventional solutions, then contaminants are removed, but lens performance and patient comfort deteriorate
Solution Approach 1:
The patent employs a composite formulation containing hyaluronic acid combined with other compatible ingredients that work synergistically. This composite approach allows effective contaminant removal through gentle surfactants while hyaluronic acid provides lubrication and comfort, preventing the deterioration of lens performance and patient comfort that occurs with conventional harsh cleaning solutions
Solution Approach 2:
The patent changes the chemical parameters of the cleaning solution by using milder, more biocompatible ingredients including hyaluronic acid at optimized concentrations. This parameter change enables effective cleaning while maintaining lens performance and patient comfort, as the gentler chemistry prevents damage to the lens material and reduces irritation to the eye
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The solution maintains hyaluronic acid's stability and viscosity, providing improved cleaning, disinfecting, and rewetting capabilities while extending shelf life and reducing pH issues.
Implementation Method 1
improves stability and reduces molecular weight loss during sterilization, enhancing viscosity and shelf life
Implementation Method 2
one or more buffers
Implementation Method 3
one or more nonionic surfactants
Implementation Method 4
one or more of sodium chloride and potassium chloride
Data Source
AI summary
A contact lens treating solution includes (a) about 0.005 to about 2 wt. %, based on the total weight of the contact lens treating solution, of hyaluronic acid or a salt thereof; (b) about 0.01 to about 1 wt. %, based on the total weight of the contact lens treating solution, of erythritol; (c) one or more nonionic surfactants; (d) sodium chloride, potassium chloride or any combination thereof; and (e) one or more buffers.