Lentinus Polysaccharide Extract Activates SIRT1 for Non-Invasive Cellulite Treatment

Resolve Bottlenecks,
Find Innovative SolutionsGenerate Solutions

Solution Overview

Problem

Current methods for addressing cellulite and subcutaneous fatty deposits are invasive and cumbersome, lacking effective non-invasive solutions that target the formation and storage of excess fat at the cellular level.

Innovation Solution

A polysaccharide extract from the Lentinus genus is used to activate the expression of the SIRT1 protein in keratinocyte cells, inhibiting adipogenesis and promoting lipolysis, thereby addressing the imbalance in fat storage and metabolism.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Reliability

If invasive methods (lipoplasty, mesotherapy, iontophoresis) are used to treat cellulite and fatty deposits, then treatment effectiveness is improved, but patient discomfort and procedural complexity increase

Engineering Contradiction:

Improvetreatment effectivenessVSAvoidpatient comfort

Core Design Contradiction:

ReliabilityVSEase of operation

Solution Approach 1:

The patent replaces mechanical/invasive treatment methods with a biochemical approach using a polysaccharide extract from Lentinus edodes. This extract activates SIRT1 protein expression at the cellular level, substituting physical intervention with molecular biology-based treatment to achieve fat metabolism regulation without patient discomfort

Inventive Principle:

Principle #28Mechanics substitution (Replace mechanical system)

Solution Approach 2:

The polysaccharide extract serves as an intermediary substance that mediates between the external application and the cellular SIRT1 protein. The extract penetrates the skin and activates SIRT1 expression, which then regulates adipocyte metabolism, providing an indirect but effective treatment pathway that avoids direct mechanical intervention

Inventive Principle:

Principle #24Intermediary (Mediator)

2Reliability

If caloric restriction is used to increase SIRT1 expression and promote cell survival, then longevity is improved, but fat accumulation increases due to reduced PPAR-gamma activity

Engineering Contradiction:

Improvecell survivalVSAvoidadipose reserves

Core Design Contradiction:

ReliabilityVSQuantity of substance

Solution Approach 1:

The patent changes the activation parameter for SIRT1 from caloric restriction (which causes fat accumulation) to polysaccharide extract application. This allows selective activation of SIRT1's beneficial effects on cell survival and lipolysis while avoiding the harmful effect of increased fat storage associated with dietary restriction

Inventive Principle:

Principle #35Parameter changes

Solution Approach 2:

The patent converts the potentially harmful effect of SIRT1 activation (which can increase fat storage under certain conditions) into a beneficial effect by using polysaccharide extract to specifically enhance lipolysis and inhibit adipogenesis. The extract ensures that SIRT1 activation leads to fat breakdown rather than fat accumulation

Inventive Principle:

Principle #22Blessing in disguise (Convert harm into benefit)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The Lentinus extract significantly increases SIRT1 protein expression, leading to enhanced inhibition of fat cell formation and increased fat breakdown, providing a non-invasive and effective treatment for cellulite and subcutaneous fatty deposits.

Implementation Method 1

The Lentinus extract significantly increases SIRT1 protein expression

Methodology Applied

Scientific EffectProtein expression activation:

Implementation Method 2

Sirtuins are in fact capable of deacetylating the histones on which the DNA is wound, making it less sensitive to UV and DNases

Methodology Applied

Scientific EffectDeacetylation:

Implementation Method 3

SIRT 1 inhibits adipogenesis and increases lipolysis

Methodology Applied

Scientific EffectLipolysis:

Data Source

PatentEP2210610B1Use of extract of lentinus for the treatment of cellulite and fatty masses.

Publication Date: 2017.07.19 CASTER

Figure 1
Figure 2
Figure 3A~3C

AI summary

Polysaccharide extract (I) derived from a mushroom of Lentinusgenus for treating cellulite and subcutaneous fat deposits, is claimed. ACTIVITY : None given. MECHANISM OF ACTION : Sirt 1 activator. The ability of (I) to activate Sirt 1 was tested in HaCaT human keratinocytes. The result showed that the extract of Lentinusexhibited an increase of 500% of the amount of Sirt 1 present in keratinocytes.