Lesion Extracting Device Using Fluorescence Ratio
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Solution Overview
Problem
Current fluorescence-based cancer diagnosis techniques face challenges in distinguishing between normal and lesion parts, as well as benign and malignant tumors, due to variations in fluorescence intensity and distance from the excitation light source, leading to difficulties in accurate discrimination.
Innovation Solution
A lesion extracting device and method that control the amount of excitation light and measure fluorescence intensity, using a ratio of light changes to extract lesions based on relationships between excitation light and fluorescence intensity, with filters to isolate excitation and fluorescence, and an image processing unit for clear visualization.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If fluorescence intensity is used to discriminate lesion parts, then diagnostic information can be obtained, but discrimination accuracy deteriorates due to variations in excitation light intensity and distance
Solution Approach 1:
The patent changes the parameter from absolute fluorescence intensity to the ratio of fluorescence intensity to excitation light intensity. This ratio parameter eliminates the influence of excitation light variations and distance, enabling accurate discrimination of lesion parts regardless of these variations.
Solution Approach 2:
The patent introduces an excitation light intensity measurement as an intermediary parameter to correct the fluorescence intensity measurements. By measuring both excitation light intensity and fluorescence intensity, the system can calculate a corrected ratio that accurately reflects lesion characteristics independent of distance and light source variations.
2Loss of information
If multiple wavelengths of excitation light are used to analyze fluorescence spectrum, then more information can be obtained, but information processing complexity increases
Solution Approach 1:
The patent extracts only the essential information needed for lesion discrimination by using a specific wavelength band (380-480nm) for excitation and measuring fluorescence in a defined range (480-680nm). This extraction approach obtains sufficient diagnostic information while avoiding the complexity of full-spectrum analysis.
Solution Approach 2:
The patent segments the spectrum into specific wavelength bands for excitation (380-480nm) and fluorescence detection (480-680nm). This segmentation simplifies the information processing by focusing on relevant spectral regions rather than analyzing the entire spectrum.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This approach enables precise discrimination of normal and lesion parts, as well as benign and malignant tumors, by analyzing changes in fluorescence intensity with varying excitation light, improving diagnostic accuracy and reducing information processing complexity.
Implementation Method 1
a light source for emitting an excitation light toward a subject body to be examined... a light irradiating and receiving portion for irradiating the excitation light to the subject body and receiving fluorescence generated from the subject body
Data Source
AI summary
A lesion extracting device includes a light source for emitting an excitation light toward a subject body, a control unit for changing an amount of the excitation light, a light irradiating and receiving portion for irradiating the excitation light to the subject body and receiving fluorescence generated from the subject body, a distance holding member for holding a distance between the subject body and the light irradiating and receiving portion at a predetermined value, a measuring unit for measuring the intensity of the fluorescence received by the light irradiating and receiving portion, and an extracting unit for extracting a lesion part of the subject body based on relationships between measured values of changes in the fluorescence intensity with respect to changes in the amount of the excitation light and information regarding the changes in the amount of the excitation light, the information being obtained from the control unit.