Lesion Tissue Prosthesis Shaping via Cross-Linking Agents
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Solution Overview
Problem
Current simulated tumor prostheses cannot be shaped at temperatures between 25° C. to 60° C. and fail to simulate protein properties or exhibit curing effects after thermal ablation, limiting their effectiveness in training for thermal ablation procedures.
Innovation Solution
A method involving the combination of sodium carbonate, sodium polyacrylate, a cross-linking agent, an initiator, and an accelerator to create a lesion tissue prosthesis that can be shaped into a soft elastomer at room temperature, simulating protein solidification and caramelization at thermal ablation temperatures, with a normal tissue prosthesis covering the lesion tissue to maintain realism and allow for accurate thermal ablation practice.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Loss of time
If gel-like materials are used to simulate tumor prosthesis, then the prosthesis can be formed at low temperature, but the forming time is extremely long (24-50 hours at -20°C) and cannot be formed quickly at normal temperatures
Solution Approach 1:
The patent changes the chemical composition parameters of the gel material by adding specific cross-linking agents (polyethylene glycol diacrylate, trimethylolpropane triacrylate) and initiators (ammonium persulfate, calcium acetate) to enable the material to cure rapidly at normal temperatures (25-60°C) within minutes to hours, eliminating the need for prolonged freezing conditions
Solution Approach 2:
The patent introduces cross-linking agents and initiators as intermediary substances that mediate between the gel material and temperature conditions, enabling the gel to undergo cross-linking reactions and solidify quickly at normal temperatures without requiring extreme cold conditions
2Reliability
If gel-like tumor prosthesis is subjected to thermal ablation at 60-80°C, then the simulation is realistic, but the gel becomes hydrated and dissipates, unable to simulate solidification or caramelization
Solution Approach 1:
The patent creates a composite material system combining gel base material with cross-linking agents and initiators, forming a cross-linked gel network structure that maintains structural stability during thermal ablation while still exhibiting realistic simulation effects of solidification and caramelization
Solution Approach 2:
The patent utilizes phase transition phenomena where the gel material undergoes controlled cross-linking and solidification transitions during thermal ablation, allowing it to simulate the phase changes of real tumor tissue (solidification at 60-80°C and caramelization at higher temperatures) while maintaining structural integrity
3Measurement precision
If activated carbon pellets are used to simulate tumor tissue, then ultrasonic imaging is improved, but the hardness is higher than real tumor tissue and cannot simulate the touch during training
Solution Approach 1:
The patent applies local quality by incorporating activated carbon pellets only in specific regions or at controlled concentrations within the gel prosthesis, allowing ultrasonic imaging enhancement in those areas while maintaining overall soft tissue-like consistency and tactile realism for training purposes
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The method enables rapid shaping of the prosthesis at normal temperatures, simulates the solidification and caramelization of tumor tissue during thermal ablation, and provides a realistic ultrasound image, allowing for precise evaluation of thermal ablation procedures and temperature control.
Implementation Method 1
adding a cross-linking agent to the first mixture, and waiting for the cross-linking agent to be completely dissolved
Implementation Method 2
stirring to form a viscous colloid, and then shaping the viscous colloid to form a lesion tissue prosthesis
Implementation Method 3
can be solidified by simulating protein properties according to the operating temperature of thermal ablation
Implementation Method 4
simulating protein solidification and caramelization at thermal ablation temperatures
Implementation Method 5
Radiofrequency ablation uses electric current to conduct heat indirectly
Implementation Method 6
microwave ablation uses high-frequency vibration of water molecules to generate heat
Data Source
AI summary
A method for manufacturing a lesion tissue prosthesis that simulates protein properties is provided, which includes steps of: adding sodium carbonate and sodium polyacrylate to a first deionized water to obtain a first mixture; adding a cross-linking agent to the first mixture, and waiting for the cross-linking agent to be completely dissolved; and adding an initiator and an accelerator to the first mixture, stirring to form a viscous colloid, and then shaping the viscous colloid to form a lesion tissue prosthesis. A medical prosthesis is also provided, which is formed by a normal tissue prothesis made of an elastic colloid that covers or adheres to the lesion tissue prosthesis.