Leuconostoc HX-236 Fermentation for Cordyceps Militaris Active Release
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Current anti-aging cosmetics lack efficacy in improving cellular hypoxia and addressing skin aging issues such as decreased cell vitality, collagen loss, pigmentation, and reduced skin elasticity, while existing Cordyceps militaris products do not fully release their active ingredients.
Innovation Solution
The use of Leuconostoc sp. HX-236 for fermenting Cordyceps militaris to enhance the release of active ingredients like cordycepin and cordycepic acid, resulting in a fermentation product that regulates skin inflammation, promotes collagen endogeny, and improves skin autophagy, thereby addressing skin aging.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Quantity of substance
If conventional anti-aging cosmetics are used to provide skin hydration, then skin hydration is improved, but efficacy in improving cellular hypoxia and anti-aging is insufficient
Solution Approach 1:
The patent changes the chemical composition parameters of the fermentation medium, using Cordyceps militaris as the sole nitrogen source and optimizing carbon source composition (glucose, fructose, sucrose in specific ratios) to enhance the production of bioactive compounds with anti-aging properties while maintaining hydration benefits
Solution Approach 2:
The patent creates a composite fermentation product containing multiple active ingredients (cordycepin, cordycepic acid, peptides, extracellular polysaccharides) that work synergistically to provide both hydration and anti-aging effects, resolving the contradiction between hydration and anti-aging efficacy
2Reliability
If Cordyceps militaris is used as a raw material for skin care, then antioxidation and antibacterial effects are improved, but active ingredients are not fully released
Solution Approach 1:
The patent introduces lactic acid bacteria as an intermediary organism that ferments Cordyceps militaris, breaking down cell walls and releasing bound active ingredients through enzymatic action, thereby significantly increasing the availability of cordycepin, cordycepic acid, and other bioactive compounds
Solution Approach 2:
The patent replaces mechanical extraction methods with biological fermentation, using lactic acid bacteria enzymes to naturally break down and release active ingredients from Cordyceps militaris, achieving more complete extraction without mechanical disruption
3Quantity of substance
If lactic acid bacteria fermentation is applied to Cordyceps militaris, then content of active ingredients is increased, but manufacturing complexity increases
Solution Approach 1:
The patent employs lactic acid bacteria that naturally occur in the environment to perform self-fermentation of Cordyceps militaris, utilizing the bacteria's inherent enzymatic systems to break down and release active ingredients without requiring complex external intervention or sophisticated fermentation equipment
Solution Approach 2:
The patent optimizes fermentation parameters (temperature, pH, incubation time, bacterial inoculum size) to achieve maximum active ingredient release under simple, controllable conditions, reducing manufacturing complexity while maintaining high efficacy
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The Cordyceps militaris fermentation product with Leuconostoc sp. HX-236 increases skin collagen I expression by 2-8%, enhances cell vitality, and reduces inflammation, effectively improving skin elasticity and reducing aging signs.
Implementation Method 1
after fermentation with lactic acid bacteria, the content of active ingredients in Cordyceps militaris can be further increased
Data Source
Figure 1A~3C
Figure 4
AI summary
The present application discloses leuconostoc HX-236 and a use thereof. HX-236 takes Cordyceps militaris powder as a unique nitrogen source, and a fermentation filtrate can be obtained by means of fermentation culture. The fermentation filtrate comprises high contents of cordycepin and cordycepic acid, and can improve the expression of hypoxia-inducible factors (HIFs) 1α in cells, so that downstream signaling pathways for regulation of inflammatory response, cell autophagy, and tissue regeneration are activated, thereby alleviating the problems of skin aging such as cell viability decline, collagen loss, pigmentation, and skin elasticity reduction caused by hypoxia of the skin.