Leuconostoc mesenteroides NTM048 Strain for Intestinal Immunity
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Solution Overview
Problem
There is a limited availability of lactobacillus strains with high IgA production promoting ability, which is crucial for enhancing intestinal immunity and preventing allergic diseases, inflammatory bowel diseases, and autoimmune diseases.
Innovation Solution
The Leuconostoc mesenteroides NTM048 strain, isolated from peas, has been identified for its superior IgA production promoting ability and systemic immune system stimulating effect, and can be used as an immunostimulant in various formulations, including pharmaceutical products, food, and feed.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Adaptability or versatility
If limited lactobacillus strains are used, then the availability of IgA production promoting ability is restricted, but the diversity of immunostimulant options is reduced
Solution Approach 1:
The patent applies parameter changes by isolating and identifying a novel lactobacillus strain (Leuconostoc mesenteroides NTM048) with superior IgA production promoting ability. The strain was screened from approximately 200 lactobacillus strains isolated from various raw vegetables and pickles, representing a parameter change in strain selection and characterization that expands the available options for immunostimulants.
2Reliability
If novel lactobacillus strains are isolated and identified, then the IgA production promoting ability is enhanced, but the isolation and identification process requires intensive screening
Solution Approach 1:
The patent applies self-service by utilizing the natural occurrence of lactobacillus strains in raw vegetables and pickles as the source material. The intensive screening process leverages the inherent properties of these naturally occurring strains, allowing the research to identify superior strains (such as NTM048) without requiring complex artificial cultivation or modification systems.
Data Source
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AI summary
The present invention provides Leuconostoc mesenteroides NTM048 strain deposited under accession No. NITE BP-1519, or a mutant strain thereof or a processed bacterium thereof, and a lactobacillus preparation and an immunity (particularly intestinal immunity) stimulant, containing the lactobacillus or a processed bacterium thereof.