Leukocyte Recovery Filter with Diffusing Plate
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Solution Overview
Problem
Current methods for harvesting leukocytes from blood or blood products are inefficient, particularly in capturing and recovering desired biological fluid components like leukocytes and stem cells, which limits their application in various medical and research contexts.
Innovation Solution
A biological fluid processing device with a housing, a porous leukocyte depletion filter, and a perforated diffusing plate is used to capture leukocytes, followed by an elution process with an elution fluid to retrieve the cells, enhancing recovery efficiency by directing the fluid flow through specific paths and using multiple diffusing plates to optimize elution.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Productivity
If traditional leukocyte depletion filter devices are used to capture leukocytes, then leukocytes can be captured by the filter medium, but the recovery efficiency is low and the elution process is inefficient
Solution Approach 1:
A diffusing plate is introduced as an intermediary component between the filter medium and the outlet port. This plate facilitates the elution process by directing elution fluid through the filter medium, improving cell recovery efficiency without requiring excessive time or pressure
2Productivity
If high pressure is applied during elution to improve recovery, then more leukocytes can be recovered, but the risk of cell damage increases
Solution Approach 1:
The diffusing plate changes the pressure distribution parameters during elution. By providing a distributed flow path, it converts high localized pressure into lower distributed pressure, maintaining effective cell recovery while reducing the risk of cell damage from excessive pressure
3Productivity
If the filter medium is made more efficient to capture more leukocytes, then capture efficiency improves, but the elution difficulty increases
Solution Approach 1:
The diffusing plate serves as a mediator between the efficient filter medium and the elution fluid. It ensures that elution fluid is properly distributed through the filter medium, making the elution process easier even when using highly efficient capture media
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The device significantly improves the recovery of leukocytes and stem cells, achieving higher yields compared to traditional methods, making it suitable for applications involving cord blood, amniotic fluid, and bone marrow, while maintaining a closed system for sterile integrity.
Implementation Method 1
a porous filter having a first surface and a second surface, disposed in the housing across the fluid flow path
Implementation Method 2
a first perforated diffusing plate having a first surface and a second surface, disposed in the housing across the fluid flow path, wherein the first diffusing plate is disposed in the housing between the second surface of the porous filter and the outlet portion port(s)
Data Source
Figure 1
Figure 2
Figure 3A~3F
AI summary
Devices, systems, and methods for obtaining one or more desired fluid components, using a back-flushable filter device comprising a filter and at least one diffusing plate, are disclosed.