Levan Matrix Fast Dissolving Tablets Strength
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Solution Overview
Problem
Existing fast dissolving pharmaceutical dosage forms are fragile and brittle, lacking physical strength, making them difficult to handle and pack, and they disintegrate easily before intended use.
Innovation Solution
The development of pharmaceutical compositions with a high tensile strength, utilizing an open matrix network of levan that rapidly disintegrates upon contact with an aqueous medium or saliva, allowing for easy handling and storage similar to conventional tablets while ensuring rapid drug release within seconds.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Speed
If fast dissolving pharmaceutical dosage forms are made with conventional matrices (mannitol, fish gelatin, modified starch, pullulan, maltodextrin), then rapid disintegration is achieved, but the dosage forms become fragile and brittle with limited physical strength
Solution Approach 1:
The patent uses a composite matrix system combining levan (a polysaccharide) with other excipients to achieve both mechanical strength and rapid disintegration. The specific composite formulation includes levan as the primary matrix former, which provides structural integrity while maintaining fast dissolving properties when combined with appropriate excipients in optimized ratios.
Solution Approach 2:
The patent optimizes physical parameters including tensile strength (targeting 0.1-2.0 N/mm²), disintegration time (targeting <30 seconds), and moisture content to achieve the desired balance between handling stability and rapid dissolution. The matrix is designed with specific porosity and density parameters to enable both strength and fast disintegration.
2Strength
If the matrix is made to have high tensile strength for easy handling and storage, then the dosage form can withstand pressure and be packed properly, but the disintegration time increases
Solution Approach 1:
The levan-based matrix is designed with a controlled porous structure that provides mechanical strength through the three-dimensional network while the porosity allows rapid penetration of saliva and aqueous media. The pore size and distribution are optimized to maintain structural integrity during handling but enable quick water uptake and disintegration in the oral cavity.
Solution Approach 2:
The matrix exhibits dynamic properties where it maintains a stable, strong structure under dry conditions for handling and storage, but undergoes rapid structural transformation upon contact with saliva or aqueous media. The levan network is designed to be stable in the absence of water but rapidly hydrate and disintegrate when exposed to moisture, providing time-dependent mechanical property changes.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The compositions exhibit a balance of high tensile strength and rapid disintegration, enabling secure handling and storage, with at least 80% of the dosage form dissolving in under 30 seconds, enhancing the convenience and efficacy of drug delivery.
Implementation Method 1
the open matrix network is comprised of levan... the matrix rapidly disintegrating upon contact with an aqueous solution or with saliva
Implementation Method 2
the composition rapidly disintegrates when contacted with an aqueous medium or with saliva... at least 80% of the composition is disintegrated in an aqueous medium or in saliva in less than 30 seconds
Data Source
AI summary
The subject invention is directed to a pharmaceutical composition comprising an open matrix network carrying a pharmaceutically active ingredient, wherein the open matrix network comprises levan.