Lateral Flow Assay Housing with Integrated Sample Delivery Mechanism
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Solution Overview
Problem
Existing lateral flow assay devices lack a mechanism to control the amount of sample applied, leading to errors and inconsistent results due to the need for external tools like pipettes.
Innovation Solution
The development of a lateral flow assay device with an integrated mechanism for applying a predetermined quantity of sample fluid, featuring a sample port with a breakable tab and a buffer solution port, which ensures accurate and consistent sample application.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of operation
If external tools like pipettes are used to apply sample fluid, then the device can accommodate flexible sampling methods, but human error increases and result consistency deteriorates
Solution Approach 1:
The device applies sample fluid to the capillary pads automatically through its own integrated mechanism without requiring external pipettes or manual intervention. The sample port receives the sample and the device itself performs the application, eliminating human error and ensuring consistent results.
2Ease of operation
If external tools like pipettes are used to apply sample fluid, then sampling flexibility is maintained, but the need for additional external devices increases complexity
Solution Approach 1:
The sample application mechanism is merged with the lateral flow assay device itself. The sample port and integrated mechanism combine the functions of sample reception and application into a single unified device, eliminating the need for separate external pipettes or sampling tools.
Solution Approach 2:
The lateral flow assay device is designed to perform multiple functions: it can receive sample fluid through the sample port, apply the sample to capillary pads, and conduct the assay. This multi-functionality eliminates the need for separate specialized sampling devices.
3Measurement precision
If a predetermined quantity of sample fluid is applied, then measurement precision improves, but the device structure becomes more complex
Solution Approach 1:
The device automatically controls the quantity of sample applied through its integrated mechanism, using its own structures (sample port, capillary pads) to regulate and deliver the precise amount needed without external measurement tools.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This solution eliminates the need for external sampling devices, reduces human error, and ensures consistent results by applying a predetermined amount of sample fluid directly to the capillary pads.
Implementation Method 1
A lateral flow assay typically includes a series of capillary pads for transporting fluid
Data Source
AI summary
A lateral flow assay (LFA) device includes a capillary pad and a sample port that holds the sample fluid before a hole is made in a cavity surface of the sample port. The LFA device includes a breaker with a tip to make a hole in the cavity wall of the sample port causing the sample fluid held inside the compartment to be applied to the capillary pad after the start of a test.