Light-Isolated Reaction Cup Turntable for Parallel Chemiluminescence Detection
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Solution Overview
Problem
Current chemiluminescence detectors are limited by the serial operation of measuring chambers, which reduces measurement speed and accuracy due to the inability to process multiple reaction cups in parallel, leading to inefficiencies in reaction cup handling, excitation substrate addition, photon measurement, and waste liquor disposal.
Innovation Solution
A measuring chamber design with a rotationally arranged reaction cup turntable and multiple processing stations, including light-isolated areas for parallel processing, allowing simultaneous handling, measurement, and disposal of reaction cups, utilizing a substrate nozzle for excitation and a waste liquor adsorption needle for efficient operation.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Measurement precision
If a single reaction cup is processed at a time in the measuring chamber, then light interference is avoided and measurement accuracy is maintained, but the measurement speed and productivity are seriously reduced
Solution Approach 1:
The measuring chamber is divided into multiple light-isolated processing stations (first reaction cup processing station, second reaction cup processing station, third reaction cup processing station, and fourth reaction cup processing station). Each station operates independently with light isolation, allowing parallel processing of multiple reaction cups while preventing light interference between stations. This segmentation enables both high-speed parallel processing and accurate measurement.
Solution Approach 2:
The patent introduces a vertical stacking dimension by arranging multiple processing stations in different spatial locations within the measuring chamber. Reaction cups are processed at different vertical levels and positions simultaneously, transforming a single sequential operation into multi-dimensional parallel operations. This dimensional expansion allows multiple reaction cups to be measured concurrently without light interference.
2Productivity
If multiple reaction cup processing stations operate in parallel, then measurement speed and productivity are improved, but light interference between stations increases and measurement precision deteriorates
Solution Approach 1:
Light isolation structures are extracted and placed between adjacent processing stations to remove the harmful light interference. The light isolation structures include light isolation walls and light isolation covers that physically separate the optical paths of different reaction cups. This extraction of light interference through structural separation enables parallel processing while maintaining measurement precision.
Solution Approach 2:
Light isolation structures serve as intermediary elements between adjacent processing stations, blocking light transmission between stations. These intermediaries (light isolation walls, light isolation covers) act as barriers that prevent chemiluminescence light from one reaction cup from interfering with the detection of another reaction cup, enabling simultaneous parallel measurement.
3Device complexity
If serial processing is used for reaction cup in-out, excitation substrate addition, photon measurement, and waste liquor disposal, then device complexity is reduced, but the measurement speed and productivity are seriously reduced
Solution Approach 1:
The reaction cup turntable serves multiple functions: it holds multiple reaction cups, transports them between processing stations, and enables parallel positioning of multiple cups at different stations simultaneously. This multi-functional component allows the system to perform reaction cup in-out, substrate addition, measurement, and waste disposal in parallel across different stations, dramatically improving productivity without proportionally increasing complexity.
Solution Approach 2:
Multiple reaction cups are pre-loaded onto the turntable at different positions before measurement begins. The turntable is configured with multiple reaction cup holding areas that can be simultaneously positioned at different processing stations. This preliminary arrangement enables parallel processing to commence immediately without sequential loading, improving measurement speed while maintaining manageable device complexity.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This design significantly enhances measurement speed and accuracy by enabling parallel processing of multiple reaction cups, reducing light interference, and improving the overall efficiency of chemiluminescence detection.
Implementation Method 1
a bio-chemiluminescence detector based on the bio-chemiluminescence immunoassay
Implementation Method 2
a photomultiplier detection component being provided at the third reaction cup processing station
Implementation Method 3
the plurality of light-isolated components can be rotated with the reaction cup turntable together relative to the upper cover, so as to divide the reaction cup turntable into a plurality of reaction cup holding areas sealed in a mutually light-isolated manner
Data Source
AI summary
The present disclosure relates to a measuring chamber, a working method of the measuring chamber, a chemiluminescence measurement method of the measuring chamber and a chemiluminescence detector. The measuring chamber includes a dark chamber, a first substrate nozzle, a photomultiplier detection component, a waste liquor adsorption needle component, a reaction cup turntable and a plurality of reaction cup processing stations; the reaction cup turntable is provided in the measuring chamber rotationally; and the plurality of reaction cup processing stations are sealed in a mutually light-isolated manner. When the instrument works, reaction cups in the reaction cup turntable are moved in the dark chamber; and after the reaction cups are moved to corresponding processing stations for processing the reaction cups, the plurality of different processing stations for processing, the reaction cups may simultaneously process the reaction cups moved to the corresponding reaction cup processing stations.