Light-Responsive Bio-Glue for Rapid Hemostasis
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Solution Overview
Problem
Current hemostatic materials lack sufficient mechanical strength and rapid bleeding control, especially in cases of heavy bleeding, due to their slow gelling speed and inadequate tissue binding force.
Innovation Solution
A light-responsive bio-glue reagent is developed, comprising natural biological macromolecules modified with photo-triggered o-nitrobenzyl groups and a photoinitiator, which undergoes crosslinking upon light irradiation, forming a strong gel that rapidly adheres to tissues and seals wounds.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Speed
If traditional hemostatic materials (fibrin glue, gelatin, collagen) are used, then they can meet general traumatic hemostasis needs, but they have poor plasticity and insufficient mechanical strength to control heavy bleeding rapidly
Solution Approach 1:
The patent combines natural biological macromolecules (gelatin, collagen, hyaluronic acid) with synthetic photopolymerizable monomers (methacryloyloxyacetic acid, ethylene glycol dimethacrylate) to create a composite hydrogel material. This composite structure provides both the biocompatibility of natural materials and the rapid crosslinking capability of synthetic polymers, achieving rapid hemostasis with sufficient mechanical strength
Solution Approach 2:
The patent introduces light-responsive parameters to control the gelation process. By using photopolymerizable groups that crosslink upon light irradiation, the material transitions from a liquid state (for easy application) to a solid gel state (for strong binding), enabling rapid hemostasis controlled by light exposure parameters
2Adaptability or versatility
If hydrogels with strong plasticity are used to adapt to complex wound shapes, then they can conform to different wound types, but their gelling speed is too slow to control heavy bleeding rapidly
Solution Approach 1:
The patent pre-equips the hydrogel precursor solution with photopolymerizable functional groups during material synthesis. Before application, the material is prepared in a liquid state with embedded photoreactive groups, allowing it to flow and adapt to complex wound shapes. Upon light irradiation, these pre-present groups rapidly crosslink, achieving fast gelling speed without sacrificing plasticity during application
3Speed
If fast-gelling hydrogels are used to stop bleeding quickly, then they can achieve rapid hemostasis, but their mechanical strength and tissue binding force are insufficient
Solution Approach 1:
The patent controls the degree of crosslinking and gelation kinetics by adjusting photopolymerization parameters (light intensity, wavelength, exposure time) and monomer concentration. This allows optimization of both gelling speed and final mechanical strength, achieving rapid hemostasis with sufficient binding force
Solution Approach 2:
The composite structure combines natural macromolecules providing tissue affinity and biocompatibility with synthetic crosslinking networks providing mechanical strength. The synergistic interaction between gelatin/collagen/hyaluronic acid and the photopolymer crosslinked matrix achieves both rapid gelling and strong mechanical properties
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The bio-glue achieves rapid hemostasis and tissue repair by generating aldehyde groups upon light exposure, forming strong chemical bonds with wound tissues, effectively controlling bleeding and promoting wound healing within seconds.
Implementation Method 1
a photoinitiator and /or deionized water, wherein the light-responsive crosslinking group is methacrylamide or methacrylic anhydride
Implementation Method 2
a natural biological macromolecule modified with photo-triggered o-nitrobenzyl groups, which undergoes crosslinking upon light irradiation, forming a strong gel that rapidly adheres to tissues
Data Source
Figure 1
Figure 2~3H
Figure 4~4F
AI summary
The purpose of the present invention is to provide a light control agent and explore its application, and is expected to improve the tissue binding force and convenience of the existing biological glue material by providing a new reagent or material for biological damage or hemostasis. In one of embodiment, this invention provides an agent for repairing biological damage or hemostasis, wherein the agent comprises a natural biological macromolecule modified by the photo-responsive cross-linking group.