Wearable Light Therapy for Red Blood Cell Disaggregation
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Solution Overview
Problem
Current treatments for pulmonary hypertension are inadequate, with no known cure and existing medications having significant side effects and drug interactions, and there is a need for a non-pharmacological method to treat respiratory diseases effectively.
Innovation Solution
A wearable light-emitting device that emits light at specific wavelengths (625-670 nanometers) pulsed at 432 milliseconds to disaggregate red blood cells, potentially used with methylene blue to treat pulmonary hypertension and respiratory diseases like COVID-19, avoiding skin burning through controlled timing.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Stress or pressure
If medications are used to treat pulmonary hypertension, then blood pressure can be controlled, but side effects and drug interactions occur
Solution Approach 1:
The patent replaces pharmacological treatment with a physical light therapy system. LEDs emitting specific wavelengths (625-670 nanometers) are applied to the skin to disaggregate red blood cells and treat pulmonary hypertension, eliminating the need for drugs and their associated side effects while maintaining blood pressure control
Solution Approach 2:
The patent introduces methylene blue as a photosensitizing intermediary substance. When combined with light at specific wavelengths, methylene blue enhances the disaggregation of red blood cells and provides antiviral activity against SARS-CoV-2, creating a non-pharmacological treatment pathway that avoids direct drug-side effect profiles
2Reliability
If continuous light is emitted to treat respiratory diseases, then treatment effectiveness increases, but skin burning may occur
Solution Approach 1:
The patent employs pulsed light emission with alternating wavelengths at a frequency of 432 milliseconds. This periodic action delivers therapeutic doses of light energy to disaggregate red blood cells and treat respiratory diseases while providing intervals that prevent excessive heat accumulation and skin burning
Solution Approach 2:
The patent uses dynamic control of LED wavelengths and pulsing patterns. The system alternates between different wavelengths (625nm and 670nm) and adjusts pulse duration (60 nanoseconds on, 40 nanoseconds off) to optimize treatment effectiveness while dynamically preventing thermal damage to skin tissue
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The device provides a non-invasive, drug-free treatment for pulmonary hypertension and respiratory diseases by photo-activating molecules, effectively disaggregating red blood cells and interacting with pathogens, with the combination of light and methylene blue showing promise in treating COVID-19.
Implementation Method 1
A wearable light-emitting device that emits light at specific wavelengths (625-670 nanometers) pulsed at 432 milliseconds to disaggregate red blood cells
Implementation Method 2
Another objective of the invention is to provide a system which will photo-activate light sensitive molecules in the human body
Data Source
AI summary
A prosthetic liner for use with a prosthetic socket that has a thermoplastic elastomeric (TPE) layer that is in contact with the amputee's residual limb. The TPE layer is not uniform in thickness but has ridges to extend circumferentially around the TPE layer. A fabric exterior layer covers the outer surface of the TPE layer conforming to the ridges and is used as a substrate to form a mechanical bond to an elastomeric material. Impregnating the elastomeric material within the fabric exterior occurs by applying an uncured material to the fabric exterior layer and onto at least the apex surfaces located within the sealing regions thereby creating an air tight boundary layer when inserted into a socket. When a vacuum is applied the air is evacuated from the volume below the seal layer.