Light-Tuned Nano-Gap Sensing for DNA Sequence Analysis
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Solution Overview
Problem
Existing DNA analysis technologies face challenges in accurately controlling nano gaps, leading to difficulties in rapid and precise DNA sequence analysis, particularly due to issues with noise and alignment of sensing electrodes.
Innovation Solution
A DNA analysis device utilizing a photosensitive organic layer that expands or contracts in response to light, allowing precise control of the nano gap between sensing electrodes, minimizing noise, and enabling quick and accurate DNA base sequence analysis.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Productivity
If a nano gap is formed between sensing electrodes for DNA analysis, then DNA sequence analysis speed is improved, but control precision of the nano gap is worsened
Solution Approach 1:
The patent uses a photosensitive organic layer that can dynamically change its thickness in response to light irradiation, allowing the nano gap between sensing electrodes to be adjusted from a static structure to a dynamic one. This enables real-time control of the gap size to optimize both analysis speed and precision.
Solution Approach 2:
The patent changes the physical parameter of the photosensitive organic layer (thickness) through light irradiation, which directly controls the nano gap distance. By varying the irradiation conditions, the gap size can be precisely tuned to achieve optimal performance for different analysis requirements.
2Loss of time
If the nano gap is reduced for faster DNA analysis, then analysis time is improved, but noise increases
Solution Approach 1:
The dynamic adjustment capability allows the system to optimize the nano gap size for each specific analysis task, reducing the gap to minimize analysis time when needed, and enlarging it when noise reduction is the priority, thus resolving the trade-off between speed and noise.
3Device complexity
If the nano gap is controlled without a photosensitive layer, then device complexity is reduced, but alignment precision of tip electrodes is worsened
Solution Approach 1:
The photosensitive organic layer serves as an intermediary element between the substrate and the sensing electrodes, providing a controllable mechanism for precise alignment. This intermediary layer enables accurate positioning without requiring complex alignment systems or procedures.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The device achieves precise alignment of tip electrodes, reduces noise, and allows for rapid and accurate DNA base sequence analysis by simply adjusting the nano gap through light-activated deformation of the photosensitive organic layer.
Implementation Method 1
a photosensitive organic layer configured to be disposed on the substrate, and expanded or contracted by reacting to light
Data Source
AI summary
According to an aspect of the present disclosure, a DNA analysis device includes a substrate; a photosensitive organic layer configured to be disposed on the substrate, and expanded or contracted by reacting to light; a pair of sensing electrodes disposed on the photosensitive organic layer, and spaced apart from each other with a nano gap; and a light irradiation unit configured to irradiate the light to the photosensitive organic layer, and when the photosensitive organic layer is deformed, the nano gap between the pair of sensing electrodes is varied. Accordingly, the nano gap is simply and precisely adjusted by using the photosensitive organic layer which reacts to light to enhance DNA analysis accuracy.