Lignan Cosmetic Formulations for Testosterone Modulation
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Solution Overview
Problem
Current cosmetic formulations do not effectively address aesthetic disorders resulting from abnormal testosterone levels, despite the known biological properties of lignans and neolignans, such as anti-inflammatory and antioxidant effects, without mentioning their impact on testosterone modulation.
Innovation Solution
Compositions containing honokiol or magnolol, used topically, modulate testosterone levels by inhibiting aromatase and 5-α reductase type I, with specific concentration ranges stimulating or inhibiting testosterone production, thereby treating or preventing skin changes and hair loss associated with testosterone imbalances.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If lignans and neolignans are used in cosmetic formulations for their anti-inflammatory and antioxidant properties, then skin protection and anti-aging effects are improved, but their ability to modulate testosterone levels is not addressed
Solution Approach 1:
The patent applies multi-functionality by demonstrating that lignans and neolignans serve dual purposes: their traditional anti-inflammatory and antioxidant skin protection functions, plus a newly discovered testosterone modulation function. This allows a single ingredient to address multiple skin concerns including hormonal acne, hair loss, and aging related to testosterone imbalances.
2Shape
If conventional cosmetic formulations address skin aging and inflammation, then skin appearance is improved, but aesthetic disorders resulting from abnormal testosterone levels are not effectively treated
Solution Approach 1:
The patent applies parameter changes by modifying the chemical concentration parameters of lignans and neolignans in cosmetic formulations. By optimizing concentrations within specific ranges, the formulation achieves effective testosterone modulation while maintaining skin protection benefits, thereby treating hormonal skin disorders without compromising overall skin appearance.
3Ease of operation
If lignans and neolignans are applied topically for skin treatment, then skin conditions are improved, but testosterone level modulation is not achieved with conventional formulations
Solution Approach 1:
The patent applies local quality by optimizing the formulation to achieve different concentrations of lignans and neolignans at the application site. The composition is designed to maintain stability and efficacy during topical storage and application, ensuring that the active compounds reach effective concentrations at the skin surface for both immediate skin treatment and systemic testosterone modulation.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The topical application of lignan and neolignan compositions effectively restores testosterone levels, addressing skin degradation and hair loss by modulating testosterone production, demonstrating a novel cosmetic use for these compounds beyond their traditional properties.
Implementation Method 1
lignans and/or neolignans, in particular lignans and/or neolignans of the honokiol or magnolol type, make it possible to modulate the level of testosterone
Implementation Method 2
it has been demonstrated that the lignans and/or neolignans defined above act, significantly, as inhibitors of aromatase, 'Sex Hormone Binding Globulin' (SGHB) and of 5-α reductase type I
Data Source
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AI summary
The use of compositions including at least one lignane and/or neolignane, or at least one plant extract containing one of said lignanes and/or neolignanes, as an active agent for pharmaceutical, dermatological or cosmetic use for the purpose of modulating testosterone levels in order to treat and/or prevent disease states or disfigurements resulting from a process of abnormal variation in testosterone levels. The invention also relates to the field of nutraceuticals.