Lignan Emulsion Micelle Size for Absorption Rate
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Solution Overview
Problem
Lignan-class compounds, being fat-soluble and poorly water-soluble, face challenges in absorption in the body, limiting their rapid action and effectiveness in applications such as preventing sickness from drinking and scavenging active oxygen during exercise.
Innovation Solution
An oil-in-water emulsion is created by emulsifying lignan-class compounds in a water phase, reducing oil droplet size to 100 nm or smaller, enhancing their absorption rate and allowing for quicker blood concentration achievement.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Quantity of substance
If lignan-class compounds are dissolved in fat or oil to improve solubility, then the compounds become more soluble, but the absorption rate into the body remains slow
Solution Approach 1:
The patent changes the physical parameters of the oil phase by controlling its average particle size to 100 nm or smaller through ultrasonic treatment and homogenization. This parameter change transforms the oil phase into fine micelles that are rapidly absorbed in the intestine, thereby resolving the contradiction between maintaining solubility and improving absorption rate.
Solution Approach 2:
The patent segments the oil phase containing lignan-class compounds into extremely fine micelles with average particle size of 100 nm or smaller. This segmentation increases the surface area and facilitates rapid absorption in the intestine, solving the problem of slow absorption while maintaining the fat-soluble nature of the compounds.
2Loss of time
If lignan-class compounds are administered to achieve quick action effects, then the therapeutic benefit is improved, but the poor water solubility limits absorption
Solution Approach 1:
The patent uses an oil phase consisting of fine micelles as an intermediary carrier for lignan-class compounds. This intermediary system allows the fat-soluble compounds to be delivered in a water-dispersible form that is rapidly absorbed in the intestine, achieving quick therapeutic effects while overcoming the water solubility limitation.
Solution Approach 2:
The patent changes the particle size parameter of the oil phase to 100 nm or smaller, which fundamentally alters the absorption characteristics. This parameter change enables rapid intestinal absorption and quick achievement of therapeutic effects, resolving the contradiction between quick action requirement and poor solubility.
3Quantity of substance
If the particle size of fat-soluble substances is reduced to improve absorption, then the total amount of absorption is improved, but the rate of absorption is not enhanced
Solution Approach 1:
The patent applies extreme segmentation by reducing the oil phase particle size to 100 nm or smaller through ultrasonic treatment and homogenization. This level of segmentation not only improves total absorption but also dramatically enhances the absorption rate by creating a large surface area that is rapidly taken up by the intestine.
Solution Approach 2:
The patent critically changes the particle size parameter to 100 nm or smaller, which is the key differentiator from conventional emulsions. This parameter change simultaneously achieves both high total absorption and high absorption rate, resolving the contradiction identified in the prior art.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This approach significantly shortens the time to reach maximum blood concentration and increases the maximum blood concentration of lignan-class compounds, enabling faster action as antioxidants before exercise or as alcohol metabolism improvers after drinking.
Implementation Method 1
an oil-in-water emulsion comprising a water phase and an oil phase emulsified in the water phase
Implementation Method 2
wherein the oil phase has an average particle size of 100 nm or smaller
Data Source
AI summary
An object of the present invention is to increase the rate at which lignan-class compounds are absorbed into the body, namely, to provide fast-acting lignan-class compounds.Provided is an oil-in-water emulsion which comprises a water phase and an oil phase comprising at least one kind of lignan-class compounds dissolved therein and being emulsified in the water phase, wherein the oil droplets which serve as a dispersion phase in the emulsion are made finer by high-speed agitation or other method so that their average particle size is 1000 nm or smaller, preferably 500 nm or smaller, and more preferably 300 nm or smaller, whereby the rate at which lignan-class compounds are absorbed into the body is improved to impart immediate action.