Lilium candidum Extract Composition for Skin Lightening
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Solution Overview
Problem
Certain extracts of Lilium candidum, particularly from the bulb and flower, are less effective and more cytotoxic for skin lightening applications, lacking optimal melanogenesis inhibition and safety for human skin use.
Innovation Solution
Compositions comprising extracts from the whole plant, flowers, bulbs, stems, and leaves of Lilium candidum, combined with a polyunsaturated fatty acid structure, are developed to enhance UVB-induced melanogenesis inhibition and reduce cytotoxicity, offering a safer and more effective skin lightening solution.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If extracts of Lilium candidum bulb and flower are used for skin lightening, then melanogenesis inhibition is achieved, but cytotoxicity increases and effectiveness decreases
Solution Approach 1:
The invention segments the Lilium candidum plant into different parts (bulb, flower, stem, leaves) and selectively combines them in specific ratios to create an extract composition that achieves skin lightening effectiveness while reducing cytotoxicity. The segmentation principle is applied by not using the entire plant uniformly, but rather selecting and proportioning specific parts based on their individual properties.
Solution Approach 2:
The invention changes the parameters of the extract composition by controlling the ratio of polyunsaturated fatty acids to saturated fatty acids (maintaining at least 1:1 ratio), and by specifying particular chemical compounds present (such as kaempferol-3-O-β-D-xylopyranosyl-(1→2)-β-D-glucopyranoside). These parameter changes optimize both effectiveness and safety profiles.
2Reliability
If conventional Lilium candidum extracts are used, then some skin lightening effect is achieved, but UVB-induced melanogenesis inhibition is insufficient
Solution Approach 1:
The invention creates a composite extract composition by combining multiple Lilium candidum parts (bulb, flower, stem, leaves) with specific chemical compositions. This composite approach leverages the synergistic effects of different plant parts and their chemical constituents to achieve superior UVB-induced melanogenesis inhibition compared to conventional single-part extracts.
Solution Approach 2:
The invention optimizes the chemical parameters of the extract by ensuring specific compounds are present (kaempferol-3-O-β-D-xylopyranosyl-(1→2)-β-D-glucopyranoside, quercetin-3-O-β-D-xylopyranosyl-(1→2)-β-D-glucopyranoside, isoquercitrin, and linoleic acid) and by maintaining specific fatty acid ratios. These parameter changes enhance both melanogenesis inhibition and overall skin lightening efficiency.
Data Source
AI summary
Provided are compositions comprising certain extracts of Lilium Candidum and a carrier. Also provided are methods of lightening the skin comprising the step of applying to skin in need of skin lightening treatment one or more certain extracts of Lilium Candidum.