Line Scan Optical Interference Imaging for Skin Tissue Resolution

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Solution Overview

Problem

Current Optical Coherence Tomography (OCT) technologies face challenges in achieving high-resolution imaging of skin tissues, particularly in measuring layer parameters and detecting pre-cancerous cells, due to limitations in axial resolution and image quality, especially in the sub-micron scale.

Innovation Solution

A line scan interference imaging device with a two-dimensional camera, utilizing a line-shaped reflective mirror and an optical interference module to enhance light utilization and image resolution, incorporating an illumination module, interference objective module, and data processing module to produce clear cross-sectional images with reduced speckles.

Engineering Contradictions & Design Principles

VSEngineering Contradiction Analysis

1Measurement precision

If conventional OCT technology is used, then imaging capability is provided, but axial resolution and image quality are insufficient for sub-micron scale tissue structure measurement

Engineering Contradiction:
Improveaxial resolutionVSAvoidimage quality
Core Design Contradiction:
Measurement precisionVSReliability

Solution Approach 1:

The patent transitions from conventional point-by-point scanning to a line scan approach using a cylindrical lens to shape the light into a line, enabling simultaneous acquisition of multiple data points across a line. This dimensional change from 1D to 2D imaging allows for improved axial resolution while maintaining high image quality through the use of a two-dimensional camera sensor that captures the entire line scan at once.

Inventive Principle:
Principle #17Another dimension (Dimensionality change)

Solution Approach 2:

The imaging system is divided into distinct functional modules: a light source module, a cylindrical lens for line shaping, an interference objective module, and a two-dimensional camera module. This segmentation allows each component to be optimized independently, with the cylindrical lens specifically designed to create the line scan pattern and the 2D camera optimized for capturing high-resolution interference patterns, thereby achieving superior axial resolution and image quality.

Inventive Principle:
Principle #1Segmentation

2Productivity

If line scan imaging is implemented, then scanning speed is improved, but light utilization efficiency needs to be enhanced

Engineering Contradiction:
Improvescanning speedVSAvoidlight utilization efficiency
Core Design Contradiction:
ProductivityVSUse of energy by moving object

Solution Approach 1:

The line scan interference imaging device maintains continuous useful action by using a cylindrical lens to continuously shape the light into a line that scans across the sample. The two-dimensional camera continuously captures the interference patterns along the entire line scan, ensuring that every portion of the light path contributes to useful imaging data collection, thereby maximizing light utilization efficiency while maintaining high scanning speed.

Inventive Principle:
Principle #20Continuity of useful action

Solution Approach 2:

By implementing line scan imaging instead of point scanning, the system acquires data across an entire line simultaneously, increasing the productivity by capturing multiple spatial positions at once. The two-dimensional camera sensor is configured to receive light signals from the line scan, converting the optical information into electrical signals for image reconstruction, thereby achieving both high scanning speed and efficient light utilization.

Inventive Principle:
Principle #17Another dimension (Dimensionality change)

Applied Scientific Principles

This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.

Function Achieved in This Case

The solution achieves high image signal-to-noise ratio and resolution, improving image clarity and scanning speed, enabling effective imaging of skin tissues with sub-micron spatial resolution and early detection of abnormal cells.

Implementation Method 1

an optical interference module, which converts the source light to a line of light and processes light signal

Methodology Applied
Scientific EffectOptical interference: Interference

Implementation Method 2

a two-dimensional camera configured to receive a backscattered interference signal from the sample

Methodology Applied
Scientific EffectLight scattering: Scattering

Implementation Method 3

a line shaped reflective mirror on the interference objective module, thereby increasing the efficiency of utilizing light

Methodology Applied
Scientific EffectLight reflection: Reflection

Implementation Method 4

make the objective to accept incident light in an arrangement having a focal spot of the incident light between a focal plane and a principal plane of the objective

Methodology Applied
Scientific EffectLight focusing: Focusing

Data Source

PatentUS11262183B2Optical interference imaging device and its application
Publication Date: 2022.03.01 RAKU BIOMEDICAL CO LTD
  • US11262183B2 patent drawing
  • US11262183B2 patent drawing
  • US11262183B2 patent drawing

AI summary

Provided herein are devices and systems comprising an illumination module configured to provide a source light to an optical interference module, which converts the source light to a line of light and processes light signal; an interference objective module, which handles light from the optical interference module and processes light signal generated from a sample; a two-dimensional camera configured to receive a backscattered interference signal from the sample, and a data processing module which processes the interference signal into an image.