Linseed Oil-Derived Polyols for Viral and Bacterial Infection Control
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Solution Overview
Problem
Existing polyols derived from vegetable oils have not been effectively utilized as broad-spectrum antiviral agents, and there is a lack of therapeutic applications for viral and bacterial infections.
Innovation Solution
Development of vegetable oil-derived polyols, particularly from linseed oil, which are formulated into pharmaceutical compositions and can bind to viral and bacterial targets, including the CD4 binding site of HIV envelope glycoprotein gp120 and the SARS-CoV-2 spike protein, inhibiting infections by interfering with sugar alcohol metabolism of bacteria like Agrobacterium, Streptomyces, and Pseudomonas species.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If vegetable oil-derived polyols are used as therapeutic agents against viral infections, then antiviral efficacy is improved, but this application has not been previously established despite polyols having other useful properties
Solution Approach 1:
The patent demonstrates that vegetable oil-derived polyols possess multiple functions: they serve as tensioactive agents, organogelators, corrosion inhibitors, and now also as broad-spectrum antiviral agents. This multi-functionality resolves the contradiction by showing that the same polyol compounds can be applied across different therapeutic areas including viral infections, bacterial infections, and as adjuvants to enhance vaccine responses.
2Reliability
If polyols derived from vegetable oils are used as broad-spectrum antiviral agents, then treatment effectiveness is improved, but the polyols must be formulated into pharmaceutical compositions requiring additional development
Solution Approach 1:
The patent employs pharmaceutical formulations as intermediary vehicles to deliver the polyol therapeutic agents. These formulations serve as mediators that enable the polyols to reach their target sites effectively while managing the complexity of drug delivery. The formulations can be designed to optimize polyol stability, bioavailability, and targeted delivery, thereby achieving treatment effectiveness without excessive complexity.
3Reliability
If vegetable oil-derived polyols are used to inhibit bacterial sugar alcohol metabolism, then antibacterial activity is improved, but the mechanism is less understood compared to antiviral mechanisms
Solution Approach 1:
The patent extracts and highlights the specific mechanism of action against bacterial sugar alcohol metabolism as a distinct function of the polyols. By isolating this mechanism from the broader range of polyol activities, the patent provides focused understanding of how polyols inhibit bacterial growth through interference with sugar alcohol metabolism, while maintaining awareness of their other antiviral and immunomodulatory functions.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The vegetable oil-derived polyols demonstrate high efficacy in inhibiting viral and bacterial infections by binding to specific targets, offering broad-spectrum protection and potential synergy with other therapeutic agents, while being sustainable, cost-effective, and biodegradable.
Implementation Method 1
the linseed oil-derived polyol binds to the CD4 binding site of the HIV envelope glycoprotein gp120
Implementation Method 2
binds to the SARS-CoV-2 spike protein
Implementation Method 3
inhibiting infections by interfering with sugar alcohol metabolism of bacteria
Data Source
AI summary
The present invention is directed to a method of treatment or prevention of viral and/or bacterial infection comprising the administration of a polyol derived from a vegetable oil or its derivative. The vegetable oil is preferably linseed oil. The invention is also directed to a formulation comprising a vegetable oil-derived polyol.