Lipid-Coated Hydrogel Particles for Moisture Retention
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Solution Overview
Problem
Current methods for preparing hydrogel core vesicles are complex and not suitable for mass production, and existing moisturizers fail to effectively retain water in the skin due to decreased lipid synthesis and natural moisturizing factor levels with age.
Innovation Solution
Hydrogel particles are coated with lipid by dissolving lipid in an organic solvent and dispersing them with water-soluble polymers and crosslinking agents, followed by distillation under reduced pressure, allowing for efficient preparation of hydrogel particles with a lipid coating and high natural moisturizing factor content, mimicking the skin's keratinocyte structure.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If the first method (mixing hydrogel particles with liposome solution) is used to prepare hydrogel core vesicles, then the lipid bilayer can be adsorbed on the hydrogel particle surface, but pretreatment of covalently bonding fatty acid or lecithin on the hydrogel surface is required, making the process complicated
Solution Approach 1:
The invention extracts and removes the complex pretreatment step (covalent bonding of fatty acid or lecithin) from the preparation process. By using a simple mixing method without any surface modification or pretreatment of hydrogel particles, the lipid bilayer can still be effectively adsorbed on the hydrogel particle surface, thus eliminating the complicated pretreatment process while maintaining effective adsorption.
Solution Approach 2:
The hydrogel particles themselves provide the necessary properties for lipid bilayer adsorption through their inherent surface characteristics, without requiring external pretreatment or modification. The natural surface properties of the hydrogel particles enable spontaneous adsorption of the lipid bilayer when mixed with liposome solution, making the system self-sufficient.
2Reliability
If the second method (polymerization inside liposome) is used to prepare hydrogel core vesicles, then hydrogel-forming materials can be contained inside the liposome, but dilution with excess water is required to prevent polymerization of monomers not included inside the liposome, making the process complicated
Solution Approach 1:
The invention extracts and removes the dilution step with excess water from the preparation process. By carefully controlling the amount of monomer and using the liposome internal volume efficiently, the patent achieves complete encapsulation of monomers inside the liposome without requiring additional dilution, thus eliminating this complicated step while still preventing unwanted polymerization.
Solution Approach 2:
The invention changes the concentration parameters of the monomer solution and adjusts the ratio of monomer to liposome to ensure complete encapsulation. By optimizing these parameters, the system achieves effective polymerization control without requiring dilution with excess water, thus simplifying the process while maintaining reliability.
3Reliability
If existing moisturizers (humectants or occlusive moisturizers) are used to retain water in the stratum corneum, then water can be retained, but humectants feel sticky on the skin and occlusive moisturizers have difficulty maintaining emulsion stability or preparing transparent gel products
Solution Approach 1:
The invention creates a composite structure by coating hydrogel particles with lipid bilayer to form hydrogel core vesicles. This composite material combines the water retention properties of hydrogel (humectant function) with the occlusive properties of lipid bilayer, while the microencapsulated structure eliminates the sticky feel of humectants and maintains emulsion stability and transparency, thus resolving the formulation difficulties.
Solution Approach 2:
The lipid bilayer coating forms a flexible thin film around the hydrogel particles, creating a microcapsule structure. This thin film provides occlusive protection while allowing the internal hydrogel to maintain its humectant function. The microencapsulated form eliminates the sticky sensation of free humectants on the skin and enables stable emulsion formulation and transparent gel product preparation.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This method enables low-cost, efficient production of hydrogel particles with high water-holding capacity and superior moisturizing effects, suitable for both research and cosmetic applications, effectively preventing water loss and improving skin hydration.
Implementation Method 1
dissolving lipid in an organic solvent
Implementation Method 2
dispersing hydrogel particles in an organic solvent in which the lipid is dissolved
Implementation Method 3
adding water to the resulting dispersion of the above (b) and distilling under a reduced pressure
Data Source
AI summary
The present invention relates to hydrogel particles coated with lipid, which are made from dispersing hydrogel particles in an organic solvent in which lipids are dissolved, and to a method for manufacturing same. Unlike the existing method for manufacturing hydrogel core vesicles, the present invention can effectively manufacture same by using an emulsification method, without involving the steps of chemical treatment of the surface of hydrogels or dilution, thereby facilitating mass production and preventing the decrease of drug encapsulation efficiency. The present method could be widely used for research on delivery carriers of oil/water-soluble active material or cell structure reproduction and more particularly, a keratinocyte mimetic of the present invention containing natural moisturizing factors can contain a large quantity of bound water for a long time, thereby exhibiting superior capability to retain moisture and moisturize, and providing a composition for an ingredient in cosmetics for moisturizing.