Lipid Copper Complex Compositions for Solubility and Bioavailability
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Copper complexes, such as copper aspirinate and copper salicylate, suffer from low bioavailability, poor solubility, and stability issues, particularly in topical and oral dosage forms, limiting their therapeutic potential.
Innovation Solution
A lipid-based composition comprising copper complexes and unsaturated glycerides, particularly mono- and di-glycerides with cis-alkene moieties, enhances solubility and encapsulation, ensuring stability and bioavailability without the need for additional surfactants.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If copper complexes are used in topical and oral dosage forms, then therapeutic potential is improved, but solubility and stability deteriorate
Solution Approach 1:
The patent introduces lipids as intermediary substances that form complexes with copper complexes. These lipid-copper complexes serve as mediators that improve solubility and stability while maintaining therapeutic activity. The lipids act as carriers that facilitate the delivery of copper complexes through biological membranes and reduce their irritancy to the digestive tract.
Solution Approach 2:
The patent creates composite materials by combining copper complexes with lipids to form lipid-copper complexes. This composite approach allows the system to exhibit properties of both components: the therapeutic activity of copper complexes and the solubility/stability benefits of lipids. The composite structure enables high loading of copper complexes while maintaining bioavailability.
2Quantity of substance
If high concentrations of copper complexes are administered, then therapeutic efficacy is improved, but bioavailability deteriorates
Solution Approach 1:
Lipids serve as intermediaries that enable high concentrations of copper complexes to be administered while maintaining bioavailability. The lipid carrier system protects the copper complexes from degradation and facilitates their absorption, allowing therapeutic doses to be delivered effectively without compromising bioavailability.
Solution Approach 2:
The patent changes the physical and chemical parameters of copper complexes by forming lipid complexes. This transformation alters the solubility, stability, and bioavailability parameters, enabling high concentrations to be administered orally or topically without the usual deterioration in absorption and therapeutic effectiveness.
3Stability of the object's composition
If copper complexes are suspended in aqueous buffers or dissolved in organic solvents, then solubility is improved, but stability and bioavailability deteriorate
Solution Approach 1:
Lipids act as intermediary carriers that replace both aqueous buffers and organic solvents. They provide a biocompatible medium that simultaneously improves solubility of copper complexes while maintaining their stability and bioavailability. The lipid-copper complex formulation eliminates the need for problematic suspension or dissolution approaches.
Solution Approach 2:
The patent changes the solvent system from aqueous buffers or organic solvents to lipid-based carriers. This parameter change fundamentally improves the stability and bioavailability profile while maintaining adequate solubility. The lipid environment better preserves the integrity of copper complexes compared to traditional aqueous or organic systems.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The lipid-based compositions provide improved solubility and stability of copper complexes, allowing for high loadings that can be dispersed in water or solvents, suitable for various delivery methods, including through the skin or orally.
Implementation Method 1
A lipid-based composition comprising copper complexes and unsaturated glycerides, particularly mono- and di-glycerides with cis-alkene moieties, enhances solubility and encapsulation
Data Source
AI summary
The present invention relates to compositions, in particular to lipid-based compositions that solubilise and/or encapsulate (sometimes high concentrations of) copper complex(es) (and/or derivatives or analogues thereof). Such lipid-based compositions offer a variety of uses, including in their capacity as topical or ingestible formulations. Such compositions permit delivery of high concentrations of copper complex(es) (and derivatives) in a highly bioavailable form.