Lipid Matrix Core Particles for Stable Fat-Soluble Drug Loading
Find Innovative SolutionsGenerate Solutions
Solution Overview
Problem
Existing technologies face challenges in incorporating therapeutically effective amounts of fat-soluble active ingredients into multi-particulate materials while maintaining potency and shelf-stability, particularly due to the difficulty in processing and layering these ingredients on inert cores.
Innovation Solution
A composition comprising particles with a lipid matrix core containing a fat-soluble active ingredient, which can be coated with additional layers, ensuring the active ingredient is dispersed within the core and protected from degradation, thereby enhancing potency and stability.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of manufacture
If fat-soluble active ingredients are processed into dry form and micronized for layering on inert cores, then they can be incorporated into multi-particulate materials, but potency is greatly reduced and stability issues arise
Solution Approach 1:
The patent changes the physical state parameter of the fat-soluble active ingredient from dry micronized powder to liquid or semi-liquid form. This parameter change enables direct incorporation into the core material without requiring micronization processing, thereby maintaining potency and stability while achieving ease of manufacture through simple mixing processes
Solution Approach 2:
The patent creates a composite core material consisting of a lipid matrix combined with fat-soluble active ingredients in liquid or semi-liquid form. This composite approach allows the active ingredient to be uniformly distributed and stabilized within the lipid matrix, eliminating the need for micronization while maintaining both manufacturability and product reliability
2Quantity of substance
If therapeutically effective amounts of fat-soluble active ingredients are incorporated into multi-particulate materials, then product potency is improved, but shelf-stability deteriorates due to degradation
Solution Approach 1:
The patent changes the physical state parameter of the active ingredient to liquid or semi-liquid form and incorporates it into the core material in this state. This parameter change allows for better integration and protection within the matrix, maintaining stability while achieving therapeutically effective concentrations
Solution Approach 2:
The patent incorporates stabilizing components into the core formulation beforehand to prevent degradation of the fat-soluble active ingredient. This prior cushioning approach addresses stability issues before they occur during storage, allowing high concentrations of active ingredient to be maintained with improved shelf-stability
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The solution allows for the effective incorporation of fat-soluble active ingredients, such as carotenoids and cannabinoids, into oral dosage forms, maintaining potency and preventing degradation, thus addressing issues of stability and product quality.
Implementation Method 1
a core containing a lipid matrix having an active ingredient dispersed therein
Data Source
AI summary
A composition containing a plurality of particles containing a core having a lipid matrix including an active ingredient dispersed therein is disclosed. The active ingredient can include a fat-soluble active ingredient. The particles can be contained in a capsule. Also provided are methods for producing a pharmaceutical composition containing a plurality of particles containing a core having a lipid matrix including an active ingredient dispersed therein.