Lipid Curcumin Composition for High Loading Without Surfactants
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Solution Overview
Problem
Existing technologies face challenges in achieving high bioavailability, solubility, and stability of curcumin, particularly in topical and oral dosage forms, often requiring significant amounts of undesirable ingredients like polymers and surfactants.
Innovation Solution
A lipid-based composition comprising curcumin and unsaturated glycerides, such as mono- and di-glycerides with cis-alkene moieties, enhances solubility and encapsulation, while minimizing the use of surfactants and ensuring chemical stability during storage and use.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Stability of the object's composition
If curcumin is formulated in traditional delivery systems (vesicles, liposomes, nanoparticles), then solubility and bioavailability are improved, but the composition requires significant amounts of polymers and surfactants which are undesirable
Solution Approach 1:
The invention extracts and eliminates the need for polymers and surfactants from traditional curcumin delivery systems by using a simple lipid-based composition (glycerol monolaurate and glycerol monooleate) that inherently stabilizes curcumin without requiring additional excipients
Solution Approach 2:
The invention changes the fundamental parameter of the delivery system from complex polymeric/surfactant-based systems to a simple lipid-based system with specific molecular structures (glycerol monolaurate and glycerol monooleate) that provide both solubility enhancement and stability without unwanted additives
2Stability of the object's composition
If curcumin is formulated in traditional delivery systems, then bioavailability is improved, but the device complexity increases due to multiple ingredients
Solution Approach 1:
The invention removes unnecessary complex ingredients (polymers, surfactants, multiple excipients) from traditional curcumin formulations, retaining only the essential lipid components (glycerol monolaurate and glycerol monooleate) that provide bioavailability enhancement
Solution Approach 2:
The lipid components (glycerol monolaurate and glycerol monooleate) perform multiple functions simultaneously: they act as solubilizers, stabilizers, and bioavailability enhancers, eliminating the need for separate functional ingredients required in traditional formulations
3Productivity
If curcumin is loaded at high concentrations, then productivity is improved, but sedimentation occurs reducing consistency
Solution Approach 1:
The invention changes the physical-chemical parameters of the lipid matrix by using specific unsaturated glycerides with cis-alkene moieties that can accommodate high concentrations of curcumin (up to 50% w/w) while maintaining solution stability and preventing sedimentation through their molecular structure
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The composition provides high loading of curcumin with improved bioavailability, stability, and solubility, preventing sedimentation and maintaining consistency, suitable for various uses including medical treatments.
Implementation Method 1
A lipid-based composition comprising curcumin and unsaturated glycerides, such as mono- and di-glycerides with cis-alkene moieties, enhances solubility and encapsulation
Implementation Method 2
Numerous attempts in past decade have tried to address these issues through the development and testing of various drug delivery nano-/micro-systems including vesicles/liposomes, solid lipid nanoparticles (SLN), nanostructured lipid carriers (NLC)... Some of these have shown to improve curcumin solubility and bioavailability, prevent degradation of curcumin by minimizing exposure to water
Data Source
AI summary
The present invention relates to compositions, in particular to lipid-based compositions that solubilise and/or encapsulate (sometimes high concentrations of) curcumin (and/or derivatives or analogues thereof). Such lipid-based compositions offer a variety of uses, including in their capacity as topical or ingestible formulations. Such compositions permit delivery of high concentrations of curcumin (and its derivatives) in a highly bioavailable form.