Lipid Matrix Core Particles for Stable Fat-Soluble Oral Dosage
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Solution Overview
Problem
Existing technologies face challenges in incorporating therapeutically effective amounts of fat-soluble active ingredients, such as carotenoids and cannabinoids, into multi-particulate materials while maintaining potency and shelf-stability.
Innovation Solution
A composition comprising particles with a lipid matrix core containing a fat-soluble active ingredient, surrounded by one or more outer layers, which are incorporated into oral dosage forms to protect the active ingredients from degradation and maintain stability.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Ease of manufacture
If fat-soluble active ingredients are processed into dry form and micronized down to finer particles to enable layering on inert core, then the active ingredients can be incorporated into multi-particulate materials, but the potency is greatly reduced and stability issues are created in the finished particulate product
Solution Approach 1:
The patent introduces a lipid matrix as an intermediary carrier that naturally accommodates fat-soluble active ingredients. Instead of directly layering micronized fat-soluble particles onto inert cores (which causes potency loss and stability issues), the lipid matrix serves as a mediating substance that maintains the active ingredients in their native form while enabling incorporation into the multi-particulate system. The lipid matrix core replaces the traditional inert core approach for fat-soluble ingredients, providing both manufacturing feasibility and product reliability.
2Device complexity
If inert cores are used as starter material and layered with active ingredient compounds, then the multi-particulate materials can be formed, but fat-soluble active ingredients cannot be effectively incorporated while maintaining potency and shelf-stability
Solution Approach 1:
The patent fundamentally changes the parameter of the core material from inert substances (sucrose, microcrystalline cellulose) to a lipid-based matrix. This parameter change enables the core to naturally interact with and stabilize fat-soluble active ingredients through lipid-lipid compatibility, preventing degradation and maintaining shelf-stability while preserving the multi-particulate structure's complexity for effective drug delivery.
3Productivity
If fat-soluble active ingredients are incorporated into multi-particulate materials using conventional methods, then the dosage formulation can be produced, but the potency and shelf-stability are compromised
Solution Approach 1:
The patent creates a composite material system where a lipid matrix core combines with outer layers containing additional active ingredients. This composite structure allows fat-soluble active ingredients to be incorporated effectively while maintaining both potency and shelf-stability. The lipid matrix provides a stable, protective environment for the active ingredients, and the multi-layered composite structure enables efficient dosage formulation production.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
The lipid matrix core effectively retains the potency of fat-soluble ingredients, preventing degradation and ensuring stable oral dosage formulations with enhanced shelf-life and product quality.
Implementation Method 1
a core containing a lipid matrix having a fat-soluble active ingredient dispersed therein
Implementation Method 2
one or more outer layers disposed on the core... to protect the active ingredients from degradation and maintain stability
Data Source
AI summary
A composition containing a plurality of particles containing a core having a lipid matrix including an active ingredient dispersed therein is disclosed. The active ingredient can include a fat-soluble active ingredient. The particles can be contained in a capsule. Also provided are methods for producing a pharmaceutical composition containing a plurality of particles containing a core having a lipid matrix including an active ingredient dispersed therein.