Lipid Membrane Composition With Spontaneous Particle Size Control
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Solution Overview
Problem
Existing methods struggle to form fine lipid membrane structures with a particle diameter of 200 nm or less using hydrogenated phospholipids due to high phase transition temperatures, requiring complex refinement processes like microfluidization to control particle diameter, which often results in broad distributions.
Innovation Solution
A method involving the mixing of hydrogenated phospholipids with a specific polyol compound and water, where the concentration of the phospholipid is adjusted to control the particle diameter of the lipid membrane structure, allowing spontaneous formation of structures between 10 nm and 200 nm without refinement equipment.
Engineering Contradictions & Design Principles
Engineering Contradiction Analysis
1Reliability
If hydrogenated phospholipids are used to form lipid membrane structures, then oxidation resistance is improved, but particle diameter control becomes difficult due to high phase transition temperatures
Solution Approach 1:
The invention changes the chemical parameter of the phospholipid by using hydrogenated phospholipids with specific hydrogenation degrees (60-100%), which modifies the phase transition temperature and enables fine particle formation. This parameter change resolves the contradiction by making the phospholipid suitable for both oxidation resistance and fine particle diameter control (200 nm or less).
Solution Approach 2:
The invention uses composite material formulation by combining hydrogenated phospholipids with specific additives and controlling the molecular structure through partial hydrogenation. This creates a composite lipid system that maintains oxidation resistance while achieving the desired particle size distribution without requiring complex refinement equipment.
2Length of moving object
If refinement means such as microfluidizer are used to form fine lipid membrane structures, then particle diameter is reduced to 200 nm or less, but device complexity and operation difficulty increase
Solution Approach 1:
The invention enables self-service formation of fine lipid membrane structures by using hydrogenated phospholipids that spontaneously form particles of 200 nm or less through simple mixing and homogenization, without requiring complex refinement equipment like microfluidizers. The system self-organizes into the desired fine structure through the specific properties of hydrogenated phospholipids.
Solution Approach 2:
The invention replaces complex mechanical refinement systems (microfluidizers, high-pressure homogenizers) with a simplified mechanical mixing process. By substituting the mechanical refinement approach with a formulation-based approach using hydrogenated phospholipids, the device complexity is dramatically reduced while achieving the same particle size outcome.
3Manufacturing precision
If refinement conditions are extensively investigated to control particle diameter, then manufacturing precision is improved, but loss of time and productivity decrease
Solution Approach 1:
The invention performs preliminary action by pre-selecting hydrogenated phospholipids with specific hydrogenation degrees (60-100%) and molecular structures that inherently provide the desired particle size control. This preliminary formulation selection eliminates the need for extensive condition investigation during production, as the material itself dictates the particle size outcome, thereby improving productivity.
Solution Approach 2:
By changing the fundamental parameter of the phospholipid (hydrogenation degree), the invention establishes a direct relationship between material composition and particle size. This eliminates the need for time-consuming optimization of refinement conditions, as the particle diameter is determined by the material parameters rather than process parameters, significantly improving production efficiency.
Applied Scientific Principles
This section explains which scientific principles are used to turn an abstract innovation direction into a practical engineering solution.
Function Achieved in This Case
This approach enables the simple and precise control of lipid membrane structure particle diameter, facilitating easier incorporation into cosmetic products with desired permeation and appearance characteristics.
Implementation Method 1
a method for producing a lipid membrane structure-containing composition including: (A) a hydrogenated phospholipid having an acid value of 5 mg KOH/g or more; (B) a compound represented by the following formula 1... mixing the component (A), the component (B), and the component (C) to obtain a dispersion in which a lipid membrane structure having a particle diameter of 10 nm or more and 200 nm or less is spontaneously formed
Data Source
AI summary
The particle diameter of a lipid membrane structure can be controlled by a simple method when producing the lipid membrane structure. A method for producing a lipid membrane structure-containing composition includes: (A) a hydrogenated phospholipid having an acid value of 5 mg KOH/g or more; (B) a compound represented by formula 1; and (C) water. The method includes a dispersing step of mixing the component (A), the component (B), and the component (C) to obtain a dispersion in which a lipid membrane structure having a particle diameter of 10 nm or more and 200 nm or less is spontaneously formed. The dispersing step includes determining the concentration of the component (A) in the dispersion depending on the target particle diameter of the lipid membrane structure included in the lipid membrane structure-containing composition.